PDF(Pubmed)
Abstract：
Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures. Therefore, enhancing our understanding of chemokines is critical for developing appropriate treatment of TMJ. In this review, we discuss chemokines including MCP-1, MIP-1α, MIP-3a, RANTES, IL-8, SDF-1, and fractalkine that are known to be involved in TMJ diseases. In addition, we present novel findings that CCL2 is involved in β-catenin-mediated TMJ osteoarthritis (OA) and potential molecular targets for the development of effective therapies. The effects of common inflammatory factors, IL-1β and TNF-α, on chemotaxis are also described. In conclusion, this review aims to provide a theoretical basis for future chemokine-targeted therapies for TMJ OA.
摘要：
颞下颌关节疾病（TMD）是影响咀嚼肌肉和将下颌骨连接到颅底的关节的病症。虽然TMJ疾病与症状有关，原因没有得到很好的证明。趋化因子通过促进趋化性炎症细胞破坏关节滑膜,软骨，软骨下骨,和其他结构。因此,增强我们对趋化因子的了解对于开发TMJ的适当治疗至关重要。在这次审查中,我们讨论趋化因子，包括MCP-1、MIP-1α、MIP-3a,RANTES,已知参与TMJ疾病的IL-8、SDF-1和fractalkine。此外,我们提出了新的发现,即CCL2参与β-catenin介导的TMJ骨关节炎(OA),以及开发有效治疗方法的潜在分子靶点.常见炎症因子的影响，IL-1β和TNF-α,对趋化性也有描述。总之,本综述旨在为未来TMJOA的趋化因子靶向治疗提供理论依据。
