Abstract：
(1) Background: Non-communicable diseases (NCD) are an important concern for public health because of their high rates of morbidity and mortality. A prevalent lifestyle-linked NCD is type 2 diabetes mellitus (T2D). Recently, molecular biomarkers secreted by adipocytes, called adipokines, have been linked with T2D and muscle function disturbances. However, the effects of resistance training (RT) interventions on adipokine levels in patients with T2D have not been systematically studied. (2) Methods: The PRISMA guidelines were followed. Searches for the studies were performed in the PubMed/MEDLINE and Web of Science electronic databases. Eligibility criteria included: (i) participants with T2D; (ii) RT interventions; (iii) randomized controlled trials; and (iv) measurement of serum adipokines. The PEDro scale was used to assess the methodological quality of the selected studies. Significant differences (p ≤ 0.05) and effect size were screened for each variable. (3) Results: Of the initial 2166 records, database search extraction yielded 14 studies to be included. The methodological quality of the included data was high (median PEDro score of 6.5). Analyzed adipokines in the included studies were leptin, adiponectin, visfatin, apelin, resistin, retinol-binding protein 4 (RBP4), vaspin, chemerin, and omentin. RT interventions (6-52 weeks; minimal effective duration >12 weeks) exert a meaningful effect on serum adipokine, (e.g., leptin) levels in T2D patients. (4) Conclusions: RT may be an alternative, but not an optimal, option in adipokine disruptions in T2D. Combined (i.e., aerobic and RT) long-term training may be considered the optimal intervention for treating adipokine level disturbances.
摘要：
（1）背景：非传染性疾病（NCD）因其高发病率和死亡率而成为公共卫生的重要关注点。一种流行的与生活方式相关的NCD是2型糖尿病(T2D)。最近,脂肪细胞分泌的分子生物标志物，叫做脂肪因子，与T2D和肌肉功能障碍有关。然而,抗阻训练(RT)干预对T2D患者脂肪因子水平的影响尚未得到系统研究.(2)方法:遵循PRISMA指南。在PubMed/MEDLINE和WebofScience电子数据库中对研究进行了搜索。资格标准包括：（i）患有T2D的参与者；（ii）RT干预；（iii）随机对照试验；（iv）血清脂肪因子的测量。PEDro量表用于评估所选研究的方法学质量。对每个变量筛选显著差异(p≤0.05)和效应大小。（3）结果：在最初的2166条记录中，数据库搜索提取产生了14项研究纳入.纳入数据的方法学质量较高（PEDro评分中位数为6.5分）。纳入研究中分析的脂肪因子是瘦素，脂联素,visfatin,apelin,抵抗素,视黄醇结合蛋白4（RBP4），vaspin,chemerin,和门汀。RT干预（6-52周；最小有效持续时间>12周）对血清脂肪因子产生有意义的影响，(例如，瘦素）在T2D患者中的水平。(4)结论:RT可能是一种替代方案,但不是最优的，T2D中脂肪因子破坏的选项。合并(即，有氧和RT）长期训练可被认为是治疗脂肪因子水平紊乱的最佳干预措施。
