Abstract：
Analysis of the dependency of the trabecular structure on loading conditions is essential for understanding and predicting bone structure formation. Although previous studies have investigated the relationship between loads and structural adaptations, there is a need for an in-depth analysis of this relationship based on the bone region and load specifics. In this study, the load dependency of the trabecular bone microstructure for twelve regions of interest (ROIs) in the synthetic proximal femur was quantitatively analyzed to understand the spatial characteristics under seven different loading conditions. To investigate the load dependency, a quantitative measure, called the load dependency score (LDS), was established based on the statistics of the strain energy density (SED) distribution. The results showed that for the global model and epiphysis ROIs, bone microstructures relied on the multiple-loading condition, whereas the structures in the metaphysis depended on single or double loads. These results demonstrate that a given ROI is predominantly dependent on a particular loading condition. The results confirm that the dependency analysis of the load effects for ROIs should be performed both qualitatively and quantitatively.
摘要：
分析小梁结构对负载条件的依赖性对于理解和预测骨结构形成至关重要。尽管先前的研究已经研究了载荷与结构适应性之间的关系，需要基于骨骼区域和负载细节对这种关系进行深入分析。在这项研究中,定量分析了合成股骨近端12个感兴趣区域（ROIs）的小梁骨微结构的载荷依赖性，以了解七种不同载荷条件下的空间特征。要调查加载依赖关系，定量测量，称为加载依赖性得分(LDS)，基于应变能密度(SED)分布的统计量建立。结果表明，对于全局模型和骨phyROI，骨骼微结构依赖于多重负载条件，而干干末梢的结构取决于单载荷或双载荷。这些结果表明,给定的ROI主要依赖于特定的负载条件。结果证实，ROI的负载效应的相关性分析应定性和定量地进行。
