Abstract：
Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studies concerning the use of HA in andrology was carried out on the Medline, EMBASE, and the Cochrane databases, with no time restriction up to December 2022. Penile girth enlargement (PGE) using HA proved to be safe and effective in enhancing the diameter of the penis, with durable and satisfactory outcomes in long-term follow-up. Injection of HA in the glans seems to represent an alternative treatment option for those patients with premature ejaculation (PE) who fail to respond to conventional medications. HA intra-plaque injections represent a valid option which may contribute to restore sexual activity in patients with Peyronie\'s disease (PD). The adoption of HA filler injections should always be tailored to the patient\'s peculiar anatomy and underlying condition. More robust evidence is required to achieve a uniformed consensus regarding the use of HA in andrology, and further efforts should continue to improve the current injection techniques and HA products.
摘要：
透明质酸(HA)是广泛用于不同医学领域的糖胺聚糖。我们旨在全面概述HA在男科中使用的科学证据。在Medline上进行了文献综述，以确定有关HA在男科中使用的相关研究。EMBASE,和Cochrane数据库，到2022年12月没有时间限制。使用HA的阴茎围长增大（PGE）被证明可以安全有效地增强阴茎的直径，在长期随访中具有持久和令人满意的结果。对于那些对常规药物无效的早泄（PE）患者，在龟头中注射HA似乎代表了一种替代治疗选择。HA斑块内注射是一种有效的选择，可能有助于恢复Peyronie病（PD）患者的性活动。HA填充剂注射的采用应始终适合患者的特殊解剖结构和潜在状况。需要更有力的证据才能就HA在男科的使用达成统一的共识，并应继续努力改进当前的注射技术和HA产品。
