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Abstract：
UNASSIGNED: Gastric cancer (GC) is a serious threat to human health. The clinical GC characteristics in China may be impacted by changes in people\'s lifestyles and the promotion of early GC (EGC) screening. The present study aims to evaluate the recent trends of GC characteristics in South China and search for hazardous factors limiting the survival time of GC patients.
UNASSIGNED: Data on GC patients that were hospitalized in the Department of Digestive Center, the First Affiliated Hospital, Sun Yat-sen University, from 1994 to 2019 were collected and divided into two categories according to the time when the EGC screening began in China: the PRE group (previous 13 years, 1994-2006) and the PAS group (past 13 years, 2007-2019).
UNASSIGNED: We found that, although the 5-year survival rate increased in the PAS group compared with the PRE group (P < 0.0001), patients with age ≥60 years or Borrmann type IV still had a worse prognosis. In the PAS group, the larger percentages of elderly patients and patients with Borrmann type IV in the lymphatic metastases (N1) group (41.0% vs. 51.1%, P = 0.0014) and stage IV subgroup (20.7% vs. 32.2%, P = 0.016), respectively, when compared with the PRE group, may have contributed to the poor outcome of GC. By comparing the odds ratio (OR) of 5-year overall survival (OS) in the two 13-year periods, female sex and T2 turned into risk factors because of a greater proportion of Borrmann type IV or elderly patients in the PAS group (OR = 0.983, 95% CI = 0.723-1.336 vs. OR = 1.277, 95% CI = 1.028-1.586 and OR = 1.545, 95% CI = 0.499-4.775 vs. OR = 2.227, 95% CI = 1.124-4.271, respectively).
UNASSIGNED: Despite the GC epidemiology changes, the overall prognosis of GC patients has improved in South China. However, old age and Borrmann type IV are still the major restrictions affecting the survival of GC patients, a situation which calls for additional attention.
UNASSIGNED: Data on GC patients that were hospitalized in the Department of Digestive Center, the First Affiliated Hospital, Sun Yat-sen University, from 1994 to 2019 were collected and divided into two categories according to the time when the EGC screening began in China: the PRE group (previous 13 years, 1994-2006) and the PAS group (past 13 years, 2007-2019).
UNASSIGNED: We found that, although the 5-year survival rate increased in the PAS group compared with the PRE group (P < 0.0001), patients with age ≥60 years or Borrmann type IV still had a worse prognosis. In the PAS group, the larger percentages of elderly patients and patients with Borrmann type IV in the lymphatic metastases (N1) group (41.0% vs. 51.1%, P = 0.0014) and stage IV subgroup (20.7% vs. 32.2%, P = 0.016), respectively, when compared with the PRE group, may have contributed to the poor outcome of GC. By comparing the odds ratio (OR) of 5-year overall survival (OS) in the two 13-year periods, female sex and T2 turned into risk factors because of a greater proportion of Borrmann type IV or elderly patients in the PAS group (OR = 0.983, 95% CI = 0.723-1.336 vs. OR = 1.277, 95% CI = 1.028-1.586 and OR = 1.545, 95% CI = 0.499-4.775 vs. OR = 2.227, 95% CI = 1.124-4.271, respectively).
UNASSIGNED: Despite the GC epidemiology changes, the overall prognosis of GC patients has improved in South China. However, old age and Borrmann type IV are still the major restrictions affecting the survival of GC patients, a situation which calls for additional attention.
摘要：
UNASSIGNED：胃癌（GC）严重威胁人类健康。中国人生活方式的改变和早期GC(EGC)筛查的推广可能会影响GC的临床特征。本研究旨在评估华南地区GC特征的最新趋势，并寻找限制GC患者生存时间的危险因素。
UNASSIGNED：在消化中心住院的GC患者的数据，第一附属医院,中山大学,从1994年到2019年收集并根据EGC筛查在中国开始的时间分为两类：PRE组（前13年，1994-2006年)和考绩小组(过去13年，2007-2019年)。
未经授权：我们发现，尽管与PRE组相比，PAS组的5年生存率增加（P<0.0001），年龄≥60岁或BorrmannIV型患者的预后仍较差.在PAS组中，淋巴转移（N1）组中老年患者和BorrmannIV型患者的百分比较大（41.0％vs.51.1%,P=0.0014）和IV期亚组（20.7%vs.32.2%,P=0.016),分别,与PRE组相比，可能导致GC的不良结果。通过比较两个13年期间5年总生存期（OS）的比值比（OR），女性和T2成为危险因素，因为PAS组中BorrmannIV型或老年患者的比例更高（OR=0.983，95％CI=0.723-1.336vs.OR=1.277，95%CI=1.028-1.586，OR=1.545，95%CI=0.499-4.775vs.OR=2.227，95%CI分别=1.124-4.271）。
未经批准：尽管GC流行病学发生了变化，华南地区GC患者的总体预后有所改善。然而,老年和BorrmannIV型仍然是影响GC患者生存的主要限制因素，需要额外关注的情况。
UNASSIGNED：在消化中心住院的GC患者的数据，
未经授权：我们发现，
未经批准：尽管GC流行病学发生了变化，
