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Abstract：
UNASSIGNED: Doppler ultrasonography is used to study ovarian vascular characteristics. However, the outcomes are reported with a considerable variability in literature. Here we review the differences in Doppler ultrasound-measured ovarian blood flow indices between women with and without ovarian dysfunction and seeks correlations between Doppler measures and ovarian markers.
UNASSIGNED: A literature search was conducted in electronic databases (Google Scholar, Ovid, PubMed, Science Direct, and Springer) to identify studies that used Doppler for ovarian blood flow examination and reported Doppler measures in women with and without ovarian dysfunction and/or the correlations between wDoppler indices and markers of ovarian dysfunction. After quality assessment of included studies, a meta-analysis of weighted mean differences (WMDs) between women with and without ovarian dysfunction in vascularization index (VI), flow index (FI), vascularization flow index (VFI), pulsatility index (PI) and resistance index (RI) was performed. Correlation coefficients between Doppler indices and markers of ovarian dysfunction were pooled to achieve overall estimates.
UNASSIGNED: A total of 27 studies [2,377 women with ovarian dysfunction and 308 controls; age 27.7 years, 95% confidence interval (CI): 26.4 to 29.1] were included. These studies were of moderate quality. The VI (WMD 9.75; P<0.0001), FI (WMD 2.73; P<0.0001), and VFI (WMD 1.29; P<0.0001) were significantly higher whereas PI (WMD -1.08; P=0.001) and RI (WMD -0.26; P<0.0001) were significantly lower in women with polycystic ovarian syndrome (PCOS) than in normal women. In women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), antral follicle count was positively correlated with VI (r=0.24; P=0.001), FI (r=0.42; P<0.0001), and VFI (r=0.25; P=0.002). In women with PCOS, testosterone had statistically non-significant correlations with VI (r=0.40; P=0.081), and VFI (r=0.39; P=0.063) and was inversely correlated with PI (r=-0.30; P<0.0001) and RI (r=-0.48; P<0.0001). In women with PCOS, luteinizing hormone (LH) was inversely correlated with PI (r=-0.26; P=0.086) and RI (r=-0.25; P=0.007).
UNASSIGNED: Doppler indices are found significantly different in women with and without ovarian dysfunction and have significant correlations with markers of ovarian dysfunction. These results support the use of Doppler ultrasound to examine ovarian dysfunction. High statistical heterogeneity observed herein should be studies in future investigations.
UNASSIGNED: A literature search was conducted in electronic databases (Google Scholar, Ovid, PubMed, Science Direct, and Springer) to identify studies that used Doppler for ovarian blood flow examination and reported Doppler measures in women with and without ovarian dysfunction and/or the correlations between wDoppler indices and markers of ovarian dysfunction. After quality assessment of included studies, a meta-analysis of weighted mean differences (WMDs) between women with and without ovarian dysfunction in vascularization index (VI), flow index (FI), vascularization flow index (VFI), pulsatility index (PI) and resistance index (RI) was performed. Correlation coefficients between Doppler indices and markers of ovarian dysfunction were pooled to achieve overall estimates.
UNASSIGNED: A total of 27 studies [2,377 women with ovarian dysfunction and 308 controls; age 27.7 years, 95% confidence interval (CI): 26.4 to 29.1] were included. These studies were of moderate quality. The VI (WMD 9.75; P<0.0001), FI (WMD 2.73; P<0.0001), and VFI (WMD 1.29; P<0.0001) were significantly higher whereas PI (WMD -1.08; P=0.001) and RI (WMD -0.26; P<0.0001) were significantly lower in women with polycystic ovarian syndrome (PCOS) than in normal women. In women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), antral follicle count was positively correlated with VI (r=0.24; P=0.001), FI (r=0.42; P<0.0001), and VFI (r=0.25; P=0.002). In women with PCOS, testosterone had statistically non-significant correlations with VI (r=0.40; P=0.081), and VFI (r=0.39; P=0.063) and was inversely correlated with PI (r=-0.30; P<0.0001) and RI (r=-0.48; P<0.0001). In women with PCOS, luteinizing hormone (LH) was inversely correlated with PI (r=-0.26; P=0.086) and RI (r=-0.25; P=0.007).
UNASSIGNED: Doppler indices are found significantly different in women with and without ovarian dysfunction and have significant correlations with markers of ovarian dysfunction. These results support the use of Doppler ultrasound to examine ovarian dysfunction. High statistical heterogeneity observed herein should be studies in future investigations.
摘要：
未经证实：多普勒超声检查用于研究卵巢血管特征。然而,文献报道的结果具有相当大的差异.在这里，我们回顾了有和没有卵巢功能障碍的女性之间多普勒超声测量的卵巢血流指数的差异，并寻求多普勒测量与卵巢标志物之间的相关性。
未经评估：在电子数据库中进行了文献检索(谷歌学者，奥维德,PubMed,科学直接，和Springer）以确定使用多普勒进行卵巢血流检查的研究，并报告了有和没有卵巢功能障碍的女性的多普勒测量和/或w多普勒指数与卵巢功能障碍标志物之间的相关性。在对纳入研究进行质量评估后，对有和无卵巢功能障碍的女性之间的加权平均差异（WMDs）的血管化指数（VI）的荟萃分析，流量指数（FI），血管化血流指数（VFI），搏动指数(PI)和阻力指数(RI)。将多普勒指数与卵巢功能障碍标志物之间的相关系数合并以获得总体估计。
UNASSIGNED：共27项研究[2,377名卵巢功能障碍妇女和308名对照；年龄27.7岁，95%置信区间（CI）：26.4至29.1]。这些研究质量中等。VI（WMD9.75；P<0.0001），FI（WMD2.73；P<0.0001），多囊卵巢综合征(PCOS)患者的VFI(WMD1.29;P<0.0001)显著高于正常女性,而PI(WMD-1.08;P=0.001)和RI(WMD-0.26;P<0.0001)显著低于正常女性。在接受体外受精（IVF）/卵胞浆内单精子注射（ICSI）的妇女中，窦卵泡计数与VI呈正相关(r=0.24;P=0.001),FI（r=0.42；P<0.0001），和VFI(r=0.25;P=0.002)。在患有PCOS的女性中，睾酮与VI的相关性无统计学意义(r=0.40;P=0.081),VFI(r=0.39;P=0.063)与PI(r=-0.30;P<0.0001)和RI(r=-0.48;P<0.0001)呈负相关。在患有PCOS的女性中，黄体生成素（LH）与PI（r=-0.26；P=0.086）和RI（r=-0.25；P=0.007）呈负相关。
UNASSIGNED：在有和没有卵巢功能障碍的女性中，多普勒指数有显著差异，并且与卵巢功能障碍的标志物有显著相关性。这些结果支持使用多普勒超声检查卵巢功能障碍。本文观察到的高度统计异质性应该是未来研究中的研究。
未经评估：在电子数据库中进行了文献检索(谷歌学者，
UNASSIGNED：共27项研究[2,377名卵巢功能障碍妇女和308名对照；年龄27.7岁，
UNASSIGNED：在有和没有卵巢功能障碍的女性中，多普勒指数有显著差异，并且与卵巢功能障碍的标志物有显著相关性。
