PDF(Pubmed)
Abstract：
Due to its unique clinical, immunological and molecular genetic characteristics, biclonal lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes (POEMS) syndrome is extremely rare in clinical practice, and there is no standard treatment for patients afflicted with this condition. In the present case report, a rare case of double LPL/WM with POEMS syndrome is described. The patient, a 65-year-old male, exhibited significant renal impairment and polylymphadenopathy. The patient was treated with rituximab and his symptoms were resolved following two courses of treatment. A review of the literature was performed, comparing the present case with previous cases. It is hoped that this case report will enable clinicians to gain a better understanding of this disease.
摘要：
由于其独特的临床，免疫学和分子遗传学特征，双滴状淋巴浆细胞性淋巴瘤/Waldenström巨球蛋白血症（LPL/WM）伴多发性神经病，器官肿大,内分泌病,单克隆蛋白和皮肤改变（POEMS）综合征在临床实践中极为罕见，对于患有这种疾病的患者，没有标准的治疗方法。在本案例报告中，描述了一例罕见的双LPL/WM伴POEMS综合征。病人,一个65岁的男性,表现出明显的肾功能损害和多淋巴结病。患者接受了利妥昔单抗治疗，经过两个疗程的治疗，其症状得到缓解。对文献进行了回顾，将目前的情况与以前的情况进行比较。希望此病例报告将使临床医生更好地了解这种疾病。
