PDF(Pubmed)
Abstract：
Adult granulosa cell tumours (AGCTs) of the ovary are very rare during pregnancy. To date, only five cases of ovarian AGCT in pregnancy have been reported in the literature and the patients all conceived spontaneously. We report a case of AGCT of the ovary that was incidentally discovered during a caesarean section in a patient undergoing In vitro fertilisation (IVF). To the authors\' knowledge, this is the first case of AGCT incidentally discovered during caesarean section in a pregnant patient after IVF. A 44-year-old primigravida with 39 weeks gestation was admitted to our hospital due to premature rupture of membranes in May 2019. She was treated by in vitro fertilisation due to being an elderly mother and she was pregnant after the first cycle. She was indicated for caesarean section due to conceiving following in vitro fertilisation and being an elderly mother. She gave birth to a 3,000 g baby boy and his Apgar scores were 8/1\'-9/5\'. When examining the adnexa, the left ovary had a tumour with a size of 7 × 4 × 4 cm. Left oophorectomy was performed and specimen sent to for histopathology. The histopathological diagnosis was an AGCT of the ovary. A month later, the patient received chemotherapy with Carboplatin and Paclitaxel for four cycles. After 32 months of follow-up, no recurrence was detected. In conclusion, AGCTs of the ovary are very rare during pregnancy. Pre-operative diagnosis is difficult. Conservative surgery should be considered in women who wish to have children. Patients should receive adequate counselling and long-term follow-up to ensure the highest survival rates and early detection of recurrence.
摘要：
在怀孕期间，卵巢的成人颗粒细胞肿瘤（AGCT）非常罕见。迄今为止,文献中仅报道了5例妊娠期卵巢AGCT,且患者均自行受孕.我们报告了一例卵巢AGCT病例，该病例是在接受体外受精（IVF）的患者剖腹产时偶然发现的。就作者所知，这是在IVF后妊娠患者剖腹产时偶然发现的第一例AGCT。一名44岁妊娠39周的primigravida于2019年5月因胎膜早破入院。由于是一位年迈的母亲，她接受了体外受精治疗，并且在第一个周期后怀孕。由于在体外受精后怀孕并且是一位年迈的母亲，她被建议进行剖腹产。她生了一个3,000克的男婴，他的阿普加评分为8/1-9/5。检查附件时，左卵巢肿瘤大小为7×4×4厘米。进行左卵巢切除术，并将标本送去组织病理学检查。组织病理学诊断为卵巢AGCT。一个月后,患者接受卡铂和紫杉醇化疗4个周期.经过32个月的随访，未发现复发.总之,卵巢的AGCT在怀孕期间非常罕见。术前诊断很困难。对于希望生育孩子的女性，应考虑保守手术。患者应接受充分的咨询和长期随访，以确保最高的生存率和早期发现复发。
