PDF(Pubmed)
Abstract：
UNASSIGNED: Blast induced Traumatic Brain Injury (bTBI) has become a signature casualty of military operations. Recently, military medics observed neurocognitive deficits in servicemen exposed to repeated low level blast (LLB) waves during military heavy weapons training. In spite of significant clinical and preclinical TBI research, current understanding of injury mechanisms and short- and long-term outcomes is limited. Mathematical models of bTBI biomechanics and mechanobiology of sensitive neuro-structures such as synapses may help in better understanding of injury mechanisms and in the development of improved diagnostics and neuroprotective strategies.
UNASSIGNED: In this work, we formulated a model of a single synaptic structure integrating the dynamics of the synaptic cell adhesion molecules (CAMs) with the deformation mechanics of the synaptic cleft. The model can resolve time scales ranging from milliseconds during the hyperacute phase of mechanical loading to minutes-hours acute/chronic phase of injury progression/repair. The model was used to simulate the synaptic injury responses caused by repeated blast loads.
UNASSIGNED: Our simulations demonstrated the importance of the number of exposures compared to the duration of recovery period between repeated loads on the synaptic injury responses. The paper recognizes current limitations of the model and identifies potential improvements.
UNASSIGNED: In this work, we formulated a model of a single synaptic structure integrating the dynamics of the synaptic cell adhesion molecules (CAMs) with the deformation mechanics of the synaptic cleft. The model can resolve time scales ranging from milliseconds during the hyperacute phase of mechanical loading to minutes-hours acute/chronic phase of injury progression/repair. The model was used to simulate the synaptic injury responses caused by repeated blast loads.
UNASSIGNED: Our simulations demonstrated the importance of the number of exposures compared to the duration of recovery period between repeated loads on the synaptic injury responses. The paper recognizes current limitations of the model and identifies potential improvements.
摘要：
未经证实：爆炸诱发的创伤性脑损伤（bTBI）已成为军事行动的标志性伤亡。最近,军医观察到在军事重型武器训练期间暴露于反复的低水平爆炸（LLB）波的军人的神经认知缺陷。尽管有大量的临床和临床前TBI研究，目前对损伤机制和短期和长期结果的理解有限.bTBI生物力学的数学模型和敏感神经结构（如突触）的机械生物学可能有助于更好地理解损伤机制以及改进的诊断和神经保护策略的开发。
UNASSIGNED：在这项工作中，我们建立了单个突触结构的模型，该模型将突触细胞粘附分子（CAM）的动力学与突触间隙的变形力学相结合。该模型可以解决从机械负荷的超急性期的毫秒到损伤进展/修复的数小时急性/慢性期的时间尺度。该模型用于模拟重复爆炸载荷引起的突触损伤反应。
UNASSIGNED：我们的模拟证明了与重复负荷之间的恢复期持续时间相比，暴露次数对突触损伤反应的重要性。本文认识到该模型的当前局限性，并确定了潜在的改进。
UNASSIGNED：在这项工作中，
UNASSIGNED：我们的模拟证明了与重复负荷之间的恢复期持续时间相比，暴露次数对突触损伤反应的重要性。
