PDF(Pubmed)
Abstract：
The occurrence and development of malignancies are closely related to abnormal cell cycle regulation. Myeloid leukemia factor 1 (MLF1) is a small nucleocytoplasmic shuttling protein associated with cell cycle exit, apoptosis, and certain immune functions. Therefore, it is pertinent to explore the role of MLF1 in health and diseases. Studies to date have suggested that MLF1 could act as a double-edged sword, regulating biochemical activities directly or indirectly. In hematopoietic cells, it serves as a protective factor for the development of lineages, and in malignancies, it serves as an oncogenesis factor. The diversity of its functions depends on the binding partners, including tumor inhibitors, scaffolding molecules, mitochondrial membrane proteins, and transcription factors. Emerging evidence indicates that MLF1 influences immune responses as well. This paper reviews the structure, biological function, and research progress on MLF1 in health and diseases to provide new insights for future research.
摘要：
恶性肿瘤的发生发展与细胞周期调控异常密切相关。髓系白血病因子1（MLF1）是一种与细胞周期退出有关的小核质穿梭蛋白，凋亡，和某些免疫功能。因此,探讨MLF1在健康和疾病中的作用是相关的。迄今为止的研究表明，MLF1可以充当一把双刃剑，直接或间接调节生化活动。在造血细胞中，它是谱系发展的保护因素，在恶性肿瘤中，它是一种致癌因子。其功能的多样性取决于结合伙伴，包括肿瘤抑制剂,支架分子，线粒体膜蛋白，和转录因子。新出现的证据表明MLF1也影响免疫应答。本文回顾了这一结构，生物学功能,以及MLF1在健康和疾病方面的研究进展，为今后的研究提供新的见解。
