PDF(Pubmed)
Abstract：
UNASSIGNED: Although homeostasis of the cardiovascular system is regulated by the cerebral cortex via the autonomic nervous system, the role of abnormal brain functional connectivity (FC) networks in patients with cardiac dysfunction remains unclear. Here, we report thalamus-based FC alterations and their relationship with clinical characteristics in patients with coronary heart disease (CHD).
UNASSIGNED: We employed resting-state functional magnetic resonance imaging (rs-fMRI) to acquire imaging data in twenty-six patients with CHD alongside sixteen healthy controls (HCs). Next, we performed a thalamus-based FC analysis to profile abnormal FC patterns in the whole brain. Subsequently, the mean time series of the brain regions that survived in the FC analysis were used to determine correlations with clinical parameters in patients with CHD.
UNASSIGNED: We found no statistically significant differences in demographic and clinical data between patients with CHD and HCs. Patients with CHD showed decreased FC patterns between bilateral thalami and left hemisphere, encompassing supplementary motor area, superior frontal gyrus, superior parietal gyrus, inferior parietal gyrus, middle cingulate cortex, lingual gyrus and calcarine sulcus.
UNASSIGNED: These findings not only have implications in clarifying the relationship between cerebral functional imbalance and cardiovascular system, but also provide valuable insights to guide future evaluation and management of cardiac autonomic regulation via the brain-heart axis.
UNASSIGNED: We employed resting-state functional magnetic resonance imaging (rs-fMRI) to acquire imaging data in twenty-six patients with CHD alongside sixteen healthy controls (HCs). Next, we performed a thalamus-based FC analysis to profile abnormal FC patterns in the whole brain. Subsequently, the mean time series of the brain regions that survived in the FC analysis were used to determine correlations with clinical parameters in patients with CHD.
UNASSIGNED: We found no statistically significant differences in demographic and clinical data between patients with CHD and HCs. Patients with CHD showed decreased FC patterns between bilateral thalami and left hemisphere, encompassing supplementary motor area, superior frontal gyrus, superior parietal gyrus, inferior parietal gyrus, middle cingulate cortex, lingual gyrus and calcarine sulcus.
UNASSIGNED: These findings not only have implications in clarifying the relationship between cerebral functional imbalance and cardiovascular system, but also provide valuable insights to guide future evaluation and management of cardiac autonomic regulation via the brain-heart axis.
摘要：
未经证实：尽管心血管系统的稳态是由大脑皮层通过自主神经系统调节的，脑功能连接(FC)网络异常在心功能不全患者中的作用尚不清楚.这里,我们报道了以丘脑为基础的FC改变及其与冠心病(CHD)患者临床特征的关系.
UNASSIGNED：我们采用静息态功能磁共振成像（rs-fMRI）采集26例冠心病患者和16例健康对照（HCs）的影像学数据。接下来,我们进行了基于丘脑的FC分析,分析了全脑的异常FC模式.随后，FC分析中存活的脑区的平均时间序列用于确定CHD患者与临床参数的相关性.
UNASSIGNED：我们发现CHD和HCs患者的人口统计学和临床数据没有统计学上的显著差异。CHD患者在双侧丘脑和左半球之间表现出减少的FC模式，包括辅助电机区域，额上回,顶叶上回,顶下回，中扣带皮质，舌回和钙背沟。
UNASSIGNED：这些发现不仅对阐明脑功能失衡与心血管系统之间的关系有意义，而且还提供了有价值的见解，以指导未来通过脑-心轴进行心脏自主神经调节的评估和管理。
UNASSIGNED：我们采用静息态功能磁共振成像（rs-fMRI）采集26例冠心病患者和16例健康对照（HCs）的影像学数据。
UNASSIGNED：我们发现CHD和HCs患者的人口统计学和临床数据没有统计学上的显著差异。
UNASSIGNED：这些发现不仅对阐明脑功能失衡与心血管系统之间的关系有意义，
