Abstract：
The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response. A complicated metabolic network exists in interspecies interactions between periodontal pathobionts and commensals, which can lead to the development of dysbiotic plaque. Dysbiotic subgingival microbiota undergo metabolic interactions with the host and disrupt host-microbe equilibrium. In this review, we discuss the metabolic profiles of the subgingival microbiota, the metabolic crosstalk in polymicrobial communities, including pathobionts and commensals, and the metabolic interactions between microbes and the host.
摘要：
牙周炎的发生和发展围绕微生物群菌群失调和破坏宿主反应。龈下微生物群的动态代谢活动改变了多微生物群落，塑造微环境，并调节宿主的反应。一个复杂的代谢网络存在于牙周病菌和共生菌之间的种间相互作用中，这可能导致生态失调菌斑的发展。菌龈下微生物群与宿主进行代谢相互作用并破坏宿主-微生物平衡。在这次审查中,我们讨论了龈下微生物群的代谢谱，多微生物群落中的代谢串扰，包括寄生虫和共生体,以及微生物和宿主之间的代谢相互作用。本文受版权保护。保留所有权利。
