Abstract：
BACKGROUND: Photoimmunotherapy (PIT) is a new cancer treatment based on a different mechanism from conventional treatments that combines the administration of a photoabsorber and laser illumination. PIT has two characteristics: a high selectivity of target cells and the possibility of effects beyond the illuminated area. It is thus a potentially effective treatment for a wide variety of cancers.
METHODS: We herein report a patient with oropharyngeal squamous cell carcinoma with superficial cervical lymph node recurrence. Intraoperative ultrasound confirmed the localization of the lesion and major vessels near the tumor. We punctured the tumor with catheters of laser illumination under ultrasound guidance. Laser illumination was able to be performed safely without causing serious adverse events, and the effect on the illuminated site was fully exhibited.
CONCLUSIONS: Ultrasound allows for the intraoperative monitoring of each localized area and the puncture status easily in real-time. Accurate utilization of ultrasound is extremely important in PIT.
METHODS: We herein report a patient with oropharyngeal squamous cell carcinoma with superficial cervical lymph node recurrence. Intraoperative ultrasound confirmed the localization of the lesion and major vessels near the tumor. We punctured the tumor with catheters of laser illumination under ultrasound guidance. Laser illumination was able to be performed safely without causing serious adverse events, and the effect on the illuminated site was fully exhibited.
CONCLUSIONS: Ultrasound allows for the intraoperative monitoring of each localized area and the puncture status easily in real-time. Accurate utilization of ultrasound is extremely important in PIT.
摘要：
背景：光免疫疗法（PIT）是一种新的癌症治疗方法，其机制与常规治疗方法不同，该治疗方法结合了光吸收剂和激光照射的给药。PIT具有两个特征:靶细胞的高选择性和超出照射区域的效应的可能性。因此,它是对多种癌症的潜在有效治疗。
方法：我们在此报告1例口咽部鳞状细胞癌伴颈浅表淋巴结复发的患者。术中超声证实病变和肿瘤附近主要血管的定位。我们在超声引导下用激光照射导管穿刺肿瘤。激光照明能够安全地进行，而不会引起严重的不良事件，在照明现场的效果得到了充分的体现。
结论：超声允许术中实时监测每个局部区域和穿刺状态。超声的准确利用在PIT中极为重要。
方法：我们在此报告1例口咽部鳞状细胞癌伴颈浅表淋巴结复发的患者。
结论：超声允许术中实时监测每个局部区域和穿刺状态。
