Abstract：
The ecoepidemiological panorama of paracoccidioidomycosis (PCM) is dynamic and still ongoing in Brazil. In particular, data about the oral lesions of PCM are barely explored. The aim of this study was to report the clinicopathological features of individuals diagnosed with oral PCM lesions at an oral and maxillofacial pathology service in Rio de Janeiro, Brazil, in the light of a literature review.
A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM.
Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males (n=86/90.5%), middle-aged/older adults (n=54/58.7%), and white individuals (n=40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge (n=40/23.4%) and lip/labial commissure (n=33/19.3%); however, one (n=40/42.1%) or multiple sites (n=55/57.9%) could also be affected. In 90 (94.7%) patients, \"mulberry-like\" ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected.
The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil.
A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM.
Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males (n=86/90.5%), middle-aged/older adults (n=54/58.7%), and white individuals (n=40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge (n=40/23.4%) and lip/labial commissure (n=33/19.3%); however, one (n=40/42.1%) or multiple sites (n=55/57.9%) could also be affected. In 90 (94.7%) patients, \"mulberry-like\" ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected.
The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil.
摘要：
背景：巴西的副角菌病（PCM）的生态流行病学全景是动态的，并且仍在进行中。特别是,关于PCM口腔病变的数据几乎没有探索。这项研究的目的是报告在里约热内卢的口腔颌面病理学服务中被诊断患有口腔PCM病变的个体的临床病理特征，巴西,根据文献综述。
方法：对1958年至2021年获得的口腔活检进行了回顾性研究。此外,电子搜索在PubMed进行，Embase,Scopus,WebofScience,拉丁美洲和加勒比健康科学信息中心，和巴西牙科图书馆从大型口腔PCM系列中收集信息。
结果：调查了95例口服PCM。这些表现在男性中更为常见（n=86/90.5%），中老年人（n=54/58.7%），和白人（n=40/51.9%）。最常见的影响部位是牙龈/牙槽脊（n=40/23.4％）和唇/唇连合（n=33/19.3％）；然而，一个（n=40/42.1％）或多个站点（n=55/57.9％）也可能受到影响。90例（94.7%）患者中，观察到“桑树样”溃疡/枯萎病外观。数据来自21项研究(1333例)，主要是巴西人（90.5%），发现男性（92.4％；男性/女性：11.8：1）和年龄第五和六十年的个人受影响最大（范围：7-89岁），牙龈/牙槽脊，腭,嘴唇/唇连合是最常受影响的部位。
结论：口腔PCM病变的特征与拉丁美洲先前研究中报道的特征相似。临床医生应该意识到PCM的口腔表现，重点是临床人口统计学方面和鉴别诊断，特别是考虑到巴西农村和/或城市地区出现报告病例的现象。
方法：对1958年至2021年获得的口腔活检进行了回顾性研究。
结果：调查了95例口服PCM。
结论：口腔PCM病变的特征与拉丁美洲先前研究中报道的特征相似。
