PDF(Pubmed)
Abstract：
Sleep and stress have complex interactions that are implicated in both physical diseases and psychiatric disorders. These interactions can be modulated by learning and memory, and involve additional interactions with the neuroimmune system. In this paper, we propose that stressful challenges induce integrated responses across multiple systems that can vary depending on situational variables in which the initial stress was experienced, and with the ability of the individual to cope with stress- and fear-inducing challenges. Differences in coping may involve differences in resilience and vulnerability and/or whether the stressful context allows adaptive learning and responses. We provide data demonstrating both common (corticosterone, SIH and fear behaviors) and distinguishing (sleep and neuroimmune) responses that are associated with an individual\'s ability to respond and relative resilience and vulnerability. We discuss neurocircuitry regulating integrated stress, sleep, neuroimmune and fear responses, and show that responses can be modulated at the neural level. Finally, we discuss factors that need to be considered in models of integrated stress responses and their relevance for understanding stress-related disorders in humans.
摘要：
睡眠和压力具有复杂的相互作用，涉及身体疾病和精神疾病。这些相互作用可以通过学习和记忆来调节，并涉及与神经免疫系统的额外相互作用。在本文中,我们提出，压力挑战诱导跨多个系统的综合反应，可以根据初始压力经历的情境变量而变化，以及个人应对压力和恐惧引发的挑战的能力。应对的差异可能涉及韧性和脆弱性的差异和/或压力环境是否允许适应性学习和反应。我们提供的数据证明了这两种常见的(皮质酮，SIH和恐惧行为）和区分（睡眠和神经免疫）与个体的反应能力以及相对弹性和脆弱性相关的反应。我们讨论神经回路调节综合压力，睡眠,神经免疫和恐惧反应，并表明反应可以在神经水平上调节。最后,我们讨论了综合应激反应模型中需要考虑的因素及其与理解人类应激相关疾病的相关性.
