Abstract：
Great advancements have been made in understanding the pathogenesis of SS, but there remain unmet needs for effective and targeted treatments. Glandular and extraglandular dysfunction in SS is associated with autoimmune lymphocytic infiltration that invades the epithelial structures of affected organs. Regulatory T (Treg) cells are a subset of CD4+ T lymphocytes that maintain self-tolerance during physiological conditions. Besides inhibiting excessive inflammation and autoimmune response by targeting various immune cell subsets and tissues, Treg cells have also been shown to promote tissue repair and regeneration in pathogenic milieus. The changes of quantity and function of Treg cells in various autoimmune and chronic inflammatory disorders have been reported, owing to their effects on immune regulation. Here we summarize the recent findings from murine models and clinical data about the dysfunction of Treg cells in SS pathogenesis and discuss the therapeutic strategies of direct or indirect targeting of Treg cells in SS. Understanding the current knowledge of Treg cells in the development of SS will be important to elucidate disease pathogenesis and may guide research for successful therapeutic intervention in this disease.
摘要：
在理解SS的发病机制方面取得了很大进展，但对有效和有针对性的治疗仍有未满足的需求。SS的腺体和腺外功能障碍与自身免疫淋巴细胞浸润有关，该浸润侵入受影响器官的上皮结构。调节性T(Treg)细胞是在生理条件下维持自身耐受性的CD4+T淋巴细胞的子集。除了通过靶向各种免疫细胞亚群和组织来抑制过度的炎症和自身免疫反应外，Treg细胞也已显示出促进致病环境中的组织修复和再生。Treg细胞在各种自身免疫性和慢性炎症性疾病中的数量和功能变化已有报道,由于它们对免疫调节的影响。在这里，我们总结了有关Treg细胞在SS发病机制中功能障碍的小鼠模型和临床数据的最新发现，并讨论了在SS中直接或间接靶向Treg细胞的治疗策略。了解Treg细胞在SS发育过程中的最新知识对于阐明疾病的发病机理将是重要的，并且可以指导该疾病的成功治疗干预研究。
