Abstract：
OBJECTIVE: Previous studies have shown that Rheum ribes (R. ribes) could be effective in controlling the blood glucose levels. This study was conducted to determine the effects of R. ribes supplementation on glycemic indices and apolipoproteins in patients with type 2 diabetes mellitus (T2DM).
METHODS: In the present randomized double-blind controlled trial, 60 type 2 diabetic patients aged 30-60 years with a body mass index (BMI) of 20-30 kg/m2 and hemoglobin A1c (HbA1c) of 6-8% were enrolled. Patients were randomly assigned to receive 450 mg of aqueous R. ribes extract (AG), 450 mg of ethanolic R. ribes extract (EG), or placebo (PG) three times daily for 6 weeks. At the baseline and at the end of the study, blood glucose levels, homeostatic model assessment of insulin resistance (HOMA-IR) and the homeostatic model assessment of β-cell dysfunction (HOMA-B), as well as apolipoprotein A-I (ApoA1) and apolipoprotein B (ApoB) were measured.
RESULTS: There was a significant decrease in the serum levels of insulin in AG and EG groups (P = 0.003 and P = 0.001, respectively), HOMA-IR (P = 0.01 and P = 0.001, respectively), HOMA-B (P = 0.002 and P = 0.001, respectively), ApoB (P = 0.006 and P = 0.03, respectively), ApoB/ApoA1 ratio (P = 0.016 and P = 0.04, respectively). However, a significant increase in ApoA1 (P = 0.08 and P = 0.05, respectively) with no significant changes in blood glucose, at the end of study compared to beginning values, were observed. None of the variables showed a significant change in PG. At the end of the study; while there were significant differences in insulin (P = 0.04), HOMA-IR (P = 0.03), HOMA-B (P = 0.01), ApoB (P = 0.02), and ApoB/ApoA1 ratio (P = 0.03) among the groups but ApoA1 had no significant change.
CONCLUSIONS: Consumption of R. ribes intake could have beneficial effects on insulin resistance and apolipoproteins in type 2 diabetic patients. (Registered at en.irct.ir, identification number: IRCT201410142709N31).
METHODS: In the present randomized double-blind controlled trial, 60 type 2 diabetic patients aged 30-60 years with a body mass index (BMI) of 20-30 kg/m2 and hemoglobin A1c (HbA1c) of 6-8% were enrolled. Patients were randomly assigned to receive 450 mg of aqueous R. ribes extract (AG), 450 mg of ethanolic R. ribes extract (EG), or placebo (PG) three times daily for 6 weeks. At the baseline and at the end of the study, blood glucose levels, homeostatic model assessment of insulin resistance (HOMA-IR) and the homeostatic model assessment of β-cell dysfunction (HOMA-B), as well as apolipoprotein A-I (ApoA1) and apolipoprotein B (ApoB) were measured.
RESULTS: There was a significant decrease in the serum levels of insulin in AG and EG groups (P = 0.003 and P = 0.001, respectively), HOMA-IR (P = 0.01 and P = 0.001, respectively), HOMA-B (P = 0.002 and P = 0.001, respectively), ApoB (P = 0.006 and P = 0.03, respectively), ApoB/ApoA1 ratio (P = 0.016 and P = 0.04, respectively). However, a significant increase in ApoA1 (P = 0.08 and P = 0.05, respectively) with no significant changes in blood glucose, at the end of study compared to beginning values, were observed. None of the variables showed a significant change in PG. At the end of the study; while there were significant differences in insulin (P = 0.04), HOMA-IR (P = 0.03), HOMA-B (P = 0.01), ApoB (P = 0.02), and ApoB/ApoA1 ratio (P = 0.03) among the groups but ApoA1 had no significant change.
CONCLUSIONS: Consumption of R. ribes intake could have beneficial effects on insulin resistance and apolipoproteins in type 2 diabetic patients. (Registered at en.irct.ir, identification number: IRCT201410142709N31).
摘要：
目的：以前的研究表明，大黄(R.ribes）可以有效控制血糖水平。进行这项研究以确定补充R.ribes对2型糖尿病（T2DM）患者的血糖指数和载脂蛋白的影响。
方法：在本随机双盲对照试验中，纳入60例年龄在30-60岁的2型糖尿病患者，体重指数（BMI）为20-30kg/m2，血红蛋白A1c（HbA1c）为6-8％。患者被随机分配接受450毫克水R.ribes提取物（AG），450毫克乙醇R.ribes提取物（EG），或安慰剂（PG），每天3次，共6周。在基线和研究结束时，血糖水平，胰岛素抵抗的稳态模型评估（HOMA-IR）和β细胞功能障碍的稳态模型评估（HOMA-B），以及测量载脂蛋白A-I(ApoA1)和载脂蛋白B(ApoB)。
结果：AG组和EG组的血清胰岛素水平显着降低（分别为P=0.003和P=0.001），HOMA-IR（分别为P=0.01和P=0.001），HOMA-B（分别为P=0.002和P=0.001），ApoB（分别为P=0.006和P=0.03），ApoB/ApoA1比值(分别为P=0.016和P=0.04)。然而,ApoA1（分别为P=0.08和P=0.05）显着增加，血糖无明显变化，在研究结束时，与开始值相比，被观察到。没有一个变量显示PG的显著变化。在研究结束时；虽然胰岛素存在显着差异（P=0.04），HOMA-IR（P=0.03），HOMA-B（P=0.01），ApoB（P=0.02），ApoB/ApoA1比值（P=0.03），但ApoA1无明显变化。
结论：摄入Ribes可对2型糖尿病患者的胰岛素抵抗和载脂蛋白产生有益影响。（在en注册。irct.ir,标识号:IRCT201410142709N31)。
方法：在本随机双盲对照试验中，
结果：AG组和EG组的血清胰岛素水平显着降低（分别为P=0.003和P=0.001），
结论：摄入Ribes可对2型糖尿病患者的胰岛素抵抗和载脂蛋白产生有益影响。
