Abstract：
Despite numerous research showing the association between brain network abnormalities and autism spectrum disorder (ASD), contrasting findings have been reported from broad functional underconnectivity to broad overconnectivity. Thus, the significance of rich-hub organizations in the brain functional connectome of individuals with ASD remains largely unknown. High-quality data subset of ASD (n = 45) and healthy controls (HC; n = 47) children (7-15 years old) were retrieved from the ABIDE data set, and rich-club organization and network-based statistic (NBS) were assessed from resting-state functional magnetic resonance imaging (rs-fMRI). The rich-club organization functional network (normalized rich-club coefficients >1) was observed in all subjects under a range of thresholds. Compared with HC, ASD patients had higher degree of feeder connections and lower degree of local connections (degree of feeder connections: ASD = 259.20 ± 32.97, HC = 244.98 ± 30.09, p = 0.041; degree of local connections: ASD = 664.02 ± 39.19, HC = 679.89 ± 34.05, p = 0.033) but had similar in rich-club connections. Further, nonparametric NBS analysis showed the presence of abnormal connectivity in the functional network of ASD individuals. Our findings indicated that local connection might be more vulnerable, and feeder connection may compensate for its disruption in ASD, enhancing our understanding on the mechanism of functional connectome dysfunction in ASD.
摘要：
尽管大量研究表明大脑网络异常与自闭症谱系障碍（ASD）之间存在关联，从广泛的功能连接不足到广泛的过度连接，有对比发现。因此，富中心组织在ASD患者的脑功能连接组中的意义在很大程度上仍然未知.从ABIDE数据集中检索ASD（n=45）和健康对照（HC；n=47）儿童（7-15岁）的高质量数据子集，通过静息状态功能磁共振成像（rs-fMRI）评估了丰富的俱乐部组织和基于网络的统计量（NBS）。在一定范围的阈值下，所有受试者均观察到了富俱乐部组织功能网络（归一化的富俱乐部系数>1）。与HC相比,ASD患者的馈线连接程度较高，局部连接程度较低（馈线连接程度：ASD=259.20±32.97，HC=244.98±30.09，p=0.041；局部连接程度：ASD=664.02±39.19，HC=679.89±34.05，p=0.033），但在富球杆连接中相似。Further,非参数NBS分析显示ASD个体功能网络中存在异常连接.我们的调查结果表明，本地连接可能更脆弱，馈线连接可以补偿其在ASD中的中断，增强我们对ASD中功能连接体功能障碍机制的理解。
