PDF(Pubmed)
Abstract：
The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug-loaded biopolymeric coatings for biomedical implants are highlighted.
摘要：
能够局部释放生物活性分子的结构的部署可以导致疾病的更有效治疗和可植入仿生装置的更好整合。生物聚合物涂层的战略设计可用于根据手头的任务设计最佳释放曲线。作为说明性示例，从骨骼输送药物的进步，大脑,眼,和心血管植入物进行审查。这些领域集中于强调硬和软组织植入物都可以受益于受控的局部递送。用于实现向所选组织类型的适当递送的生物聚合物的组合物，和他们相应的结果被带到了前面。最后，强调了在生物医学植入物中设计载药生物聚合物涂层的关键因素。
