Abstract：
This study investigated the role of synaptic vesicle protein 2A (SV2A) in the regulation of human induced pluripotent stem cell-derived neural stem cells (NSCs). SV2A was highly expressed in NSCs. SV2A knockdown promotes apoptosis, which was associated with an upregulation of genes involved in p53 signaling as determined by transcriptome analysis. Treatment with the small molecule p53 inhibitor pifithrin-α reversed the promotion of NSC apoptosis induced by loss of SV2A. These results demonstrate that SV2A plays an important role in regulating NSC survival via the p53 signaling pathway.
摘要：
本研究探讨了突触小泡蛋白2A(SV2A)在人诱导多能干细胞源性神经干细胞(NSCs)调控中的作用。SV2A在NSC中高度表达。SV2A敲低促进细胞凋亡，这与转录组分析确定的参与p53信号传导的基因上调有关。用小分子p53抑制剂吡虫啉-α治疗逆转了由SV2A缺失诱导的NSC凋亡的促进。这些结果表明SV2A在通过p53信号通路调节NSC存活中起重要作用。
