PDF(Pubmed)
Abstract：
UNASSIGNED: Aspergillosis is an uncommon fungal infection in which primary cutaneous sites are very rare, and most cases occur in patients with immunocompromised status. Although primary cutaneous aspergillosis is usually encountered in immunocompromised patients, it also occurs in immunocompetent individuals.
UNASSIGNED: We report a case of primary cutaneous aspergillosis in a 46-year-old immunocompetent woman with diabetes mellitus after tattooing. She presented with erythematous papules, papulopustules and a plaque on the right lower limb of more than two years duration which had failed to respond to antihistamine treatment. Histological examination of a skin biopsy sample showed oval spores in the corneous layer, a slightly thickened epidermis, and infiltrating lymphocytes and neutrophils around the blood vessels in the superficial dermis. Aspergillus fumigatus was isolated and identified in cultures. Clinical and biological examinations did not reveal any systemic localization of aspergillosis, ruling out a hypothesis of blood dissemination. Lesions resolved completely after systemic antifungal treatment with itraconazole.
UNASSIGNED: Clinical lesions of primary cutaneous aspergillosis are nonspecific and usually present as a variety of lesions, including macules, papules, nodules, plaques, purpura, blood blisters, and pustules. The nonspecific features and variety of lesions can lead to misdiagnosis and delayed treatment. Direct microscopy, microbiological culture, and histopathological examination are helpful for diagnosing primary cutaneous aspergillosis. Moreover, the physicians should be aware of the possibility of Aspergillus infection in tattooed cases.
UNASSIGNED: We report a case of primary cutaneous aspergillosis in a 46-year-old immunocompetent woman with diabetes mellitus after tattooing. She presented with erythematous papules, papulopustules and a plaque on the right lower limb of more than two years duration which had failed to respond to antihistamine treatment. Histological examination of a skin biopsy sample showed oval spores in the corneous layer, a slightly thickened epidermis, and infiltrating lymphocytes and neutrophils around the blood vessels in the superficial dermis. Aspergillus fumigatus was isolated and identified in cultures. Clinical and biological examinations did not reveal any systemic localization of aspergillosis, ruling out a hypothesis of blood dissemination. Lesions resolved completely after systemic antifungal treatment with itraconazole.
UNASSIGNED: Clinical lesions of primary cutaneous aspergillosis are nonspecific and usually present as a variety of lesions, including macules, papules, nodules, plaques, purpura, blood blisters, and pustules. The nonspecific features and variety of lesions can lead to misdiagnosis and delayed treatment. Direct microscopy, microbiological culture, and histopathological examination are helpful for diagnosing primary cutaneous aspergillosis. Moreover, the physicians should be aware of the possibility of Aspergillus infection in tattooed cases.
摘要：
未经证实：曲霉病是一种罕见的真菌感染，其原发性皮肤部位非常罕见，大多数病例发生在免疫功能低下的患者。尽管原发性皮肤曲霉病通常在免疫功能低下的患者中遇到，它也发生在有免疫能力的个体中。
未经证实：我们报告了一例46岁免疫功能正常的糖尿病患者纹身后发生原发性皮肤曲霉病的病例。她出现了红斑丘疹，丘疹性脓疱和右下肢斑块超过两年，对抗组胺治疗无效。皮肤活检样本的组织学检查显示角质层中的椭圆形孢子，表皮稍微增厚，浸润真皮浅层血管周围的淋巴细胞和中性粒细胞。在培养物中分离并鉴定了烟曲霉。临床和生物学检查未发现曲霉病的任何全身定位，排除了血液传播的假设。用伊曲康唑进行全身抗真菌治疗后，病变完全消退。
未经证实：原发性皮肤曲霉病的临床病变是非特异性的，通常表现为多种病变，包括斑疹,丘疹,结节,斑块,紫癜,血泡,还有脓疱.病变的非特异性特征和多样性可导致误诊和延迟治疗。直接显微镜,微生物培养,组织病理学检查有助于原发性皮肤曲霉病的诊断。此外，医生应该意识到纹身病例中曲霉感染的可能性。
未经证实：我们报告了一例46岁免疫功能正常的糖尿病患者纹身后发生原发性皮肤曲霉病的病例。
未经证实：原发性皮肤曲霉病的临床病变是非特异性的，通常表现为多种病变，
