PDF(Pubmed)
Abstract：
UNASSIGNED: How the prefrontal cortex (PFC) recovers its functionality following lesions remains a conundrum. Recent work has uncovered the importance of transient low-frequency oscillatory activity (LFO; < 4 Hz) for the recovery of an injured brain. We aimed to determine whether persistent cortical oscillatory dynamics contribute to brain capability to support \'normal life\' following injury.
UNASSIGNED: In this 9-year prospective longitudinal study (08/2012-2021), we collected data from the patient E.L., a modern-day Phineas Gage, who suffered from lesions, impacting 11% of his total brain mass, to his right PFC and supplementary motor area after his skull was transfixed by an iron rod. A systematic evaluation of clinical, electrophysiologic, brain imaging, neuropsychological and behavioural testing were used to clarify the clinical significance of relationship between LFO discharge and executive dysfunctions and compare E.L.´s disorders to that attributed to Gage (1848), a landmark in the history of neurology and neuroscience.
UNASSIGNED: Selective recruitment of the non-injured left hemisphere during execution of unimanual right-hand movements resulted in the emergence of robust LFO, an EEG-detected marker for disconnection of brain areas, in the damaged right hemisphere. In contrast, recruitment of the damaged right hemisphere during contralateral hand movement, resulted in the co-activation of the left hemisphere and decreased right hemisphere LFO to levels of controls enabling performance, suggesting a target for neuromodulation. Similarly, transcranial magnetic stimulation (TMS), used to create a temporary virtual-lesion over E.L.\'s healthy hemisphere, disrupted the modulation of contralateral LFO, disturbing behaviour and impairing executive function tasks. In contrast to Gage, reasoning, planning, working memory, social, sexual and family behaviours eluded clinical inspection by decreasing LFO in the delta frequency range during motor and executive functioning.
UNASSIGNED: Our study suggests that modulation of LFO dynamics is an important mechanism by which PFC accommodates neurological injuries, supporting the reports of Gage´s recovery, and represents an attractive target for therapeutic interventions.
UNASSIGNED: Fundação de Amparo Pesquisa Rio de Janeiro (FAPERJ), Universidade Federal do Rio de Janeiro (intramural), and Fiocruz/Ministery of Health (INOVA Fiocruz).
UNASSIGNED: In this 9-year prospective longitudinal study (08/2012-2021), we collected data from the patient E.L., a modern-day Phineas Gage, who suffered from lesions, impacting 11% of his total brain mass, to his right PFC and supplementary motor area after his skull was transfixed by an iron rod. A systematic evaluation of clinical, electrophysiologic, brain imaging, neuropsychological and behavioural testing were used to clarify the clinical significance of relationship between LFO discharge and executive dysfunctions and compare E.L.´s disorders to that attributed to Gage (1848), a landmark in the history of neurology and neuroscience.
UNASSIGNED: Selective recruitment of the non-injured left hemisphere during execution of unimanual right-hand movements resulted in the emergence of robust LFO, an EEG-detected marker for disconnection of brain areas, in the damaged right hemisphere. In contrast, recruitment of the damaged right hemisphere during contralateral hand movement, resulted in the co-activation of the left hemisphere and decreased right hemisphere LFO to levels of controls enabling performance, suggesting a target for neuromodulation. Similarly, transcranial magnetic stimulation (TMS), used to create a temporary virtual-lesion over E.L.\'s healthy hemisphere, disrupted the modulation of contralateral LFO, disturbing behaviour and impairing executive function tasks. In contrast to Gage, reasoning, planning, working memory, social, sexual and family behaviours eluded clinical inspection by decreasing LFO in the delta frequency range during motor and executive functioning.
UNASSIGNED: Our study suggests that modulation of LFO dynamics is an important mechanism by which PFC accommodates neurological injuries, supporting the reports of Gage´s recovery, and represents an attractive target for therapeutic interventions.
UNASSIGNED: Fundação de Amparo Pesquisa Rio de Janeiro (FAPERJ), Universidade Federal do Rio de Janeiro (intramural), and Fiocruz/Ministery of Health (INOVA Fiocruz).
摘要：
未经证实：前额叶皮层（PFC）如何在病变后恢复其功能仍然是一个难题。最近的工作已经揭示了瞬时低频振荡活动(LFO;<4Hz)对于损伤的大脑的恢复的重要性。我们旨在确定持续的皮质振荡动力学是否有助于大脑在受伤后支持“正常生活”的能力。
未经评估：在这项为期9年的前瞻性纵向研究（08/2012-2021）中，我们从病人E.L.收集数据,现代的PhineasGage,患有病变的人，影响了他大脑总量的11%,在他的头骨被铁棒固定后，他的右侧PFC和辅助运动区域。对临床的系统评价，电生理,脑成像,神经心理学和行为测试用于阐明LFO放电和执行功能障碍之间关系的临床意义，并比较E.L.神经学和神经科学史上的里程碑。
UNASSIGNED：在执行单手右手动作的过程中，有选择地招募未受伤的左半球，导致了强大的LFO的出现，脑电图检测到的大脑区域断开的标记，在受损的右半球。相比之下,在对侧手运动期间募集受损的右半球，导致左半球的共同激活，并将右半球LFO降低到能够实现性能的控制水平，提示神经调节的目标。同样，经颅磁刺激(TMS),用于在E.L.的健康半球上创建临时虚拟病变，破坏了对侧LFO的调制，扰乱行为和损害执行功能的任务。与Gage相比,推理,规划,工作记忆,社会,性和家庭行为通过降低运动和执行功能期间delta频率范围内的LFO来逃避临床检查。
未经评估：我们的研究表明，LFO动力学的调节是PFC调节神经损伤的重要机制，支持盖奇康复的报告，并代表了治疗干预的一个有吸引力的目标。
UNASIGNED：里约热内卢Pesquisa基金会（FAPERJ），里约热内卢联邦大学(校内)，和Fiocruz/卫生部（INOVAFiocruz）。
未经评估：在这项为期9年的前瞻性纵向研究（08/2012-2021）中，
UNASSIGNED：在执行单手右手动作的过程中，有选择地招募未受伤的左半球，导致了强大的LFO的出现，
未经评估：我们的研究表明，LFO动力学的调节是PFC调节神经损伤的重要机制，
UNASIGNED：里约热内卢Pesquisa基金会（FAPERJ），
