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Abstract：
Diabetes mellitus is a global public health problem with both macrovascular and microvascular complications, such as diabetic corneal neuropathy (DCN). Using in-vivo confocal microscopy, corneal nerve changes in DCN patients can be examined. Additionally, changes in the morphology and quantity of corneal dendritic cells (DCs) in diabetic corneas have also been observed. DCs are bone marrow-derived antigen-presenting cells that serve both immunological and non-immunological roles in human corneas. However, the role and pathogenesis of corneal DC in diabetic corneas have not been well understood. In this article, we provide a comprehensive review of both animal and clinical studies that report changes in DCs, including the DC density, maturation stages, as well as relationships between the corneal DCs, corneal nerves, and corneal epithelium, in diabetic corneas. We have also discussed the associations between the changes in corneal DCs and various clinical or imaging parameters, including age, corneal nerve status, and blood metabolic parameters. Such information would provide valuable insight into the development of diagnostic, preventive, and therapeutic strategies for DM-associated ocular surface complications.
摘要：
糖尿病是一个全球性的公共卫生问题，同时伴有大血管和微血管并发症。如糖尿病角膜神经病变（DCN）。使用体内共聚焦显微镜，可以检查DCN患者的角膜神经变化。此外,还观察到糖尿病角膜中角膜树突状细胞（DC）的形态和数量的变化。DC是骨髓衍生的抗原呈递细胞,其在人角膜中发挥免疫和非免疫作用。然而,角膜DC在糖尿病角膜中的作用和发病机制尚不清楚。在这篇文章中,我们对报告DCs变化的动物和临床研究进行了全面综述，包括直流密度，成熟阶段,以及角膜DC之间的关系，角膜神经,和角膜上皮，在糖尿病角膜中。我们还讨论了角膜DC的变化与各种临床或成像参数之间的关联。包括年龄,角膜神经状态，和血液代谢参数。这些信息将为诊断的发展提供有价值的见解，预防性,糖尿病相关眼表并发症的治疗策略。
