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Abstract：
UNASSIGNED: Sebaceous carcinoma (SC) of the submandibular gland is extremely rare. Owing to the low morbidity and nonspecific clinical manifestations, diagnosis is commonly delayed, which increases metastasis and mortality. To date, there have been five reported cases of SC of the submandibular gland. Here, we present a new case and review the relevant literature.
UNASSIGNED: A 36-year-old woman presented with an enlarged left submandibular gland. Clinical features included a non-tender solitary nodular mass with normal overlying skin. There were no special findings on computed tomography or ultrasound examination except for a swollen mass in the left submandibular gland. The patient underwent surgical resection. Pathological examination confirmed the diagnosis of SC with nerve infiltration. Immunohistochemical examination of this case showed positive staining for P63, P40, CK7, CK8/18, MLH1, MSH2, MSH6, and PMS2. The specimen was negative for androgen receptor, CEA, S-100, CK5/6, SOX-10, SOX-11, SMA, and GCDFP-15. The KI-67 labeling index was determined to be 15%. PAS and anti-epithelial membrane antigen were positive in partial area. The patient is still undergoing follow-up, and no metastasis or recurrence has been observed for 2 months.
UNASSIGNED: This case highlighted the fact that despite its rarity, SC should be considered as a differential diagnosis for masses located in the head and face. Early and accurate diagnosis, followed by wide surgical excision, has a favorable prognosis. Therefore, clinicians should be familiar with the clinical and pathological features of this disease.
UNASSIGNED: A 36-year-old woman presented with an enlarged left submandibular gland. Clinical features included a non-tender solitary nodular mass with normal overlying skin. There were no special findings on computed tomography or ultrasound examination except for a swollen mass in the left submandibular gland. The patient underwent surgical resection. Pathological examination confirmed the diagnosis of SC with nerve infiltration. Immunohistochemical examination of this case showed positive staining for P63, P40, CK7, CK8/18, MLH1, MSH2, MSH6, and PMS2. The specimen was negative for androgen receptor, CEA, S-100, CK5/6, SOX-10, SOX-11, SMA, and GCDFP-15. The KI-67 labeling index was determined to be 15%. PAS and anti-epithelial membrane antigen were positive in partial area. The patient is still undergoing follow-up, and no metastasis or recurrence has been observed for 2 months.
UNASSIGNED: This case highlighted the fact that despite its rarity, SC should be considered as a differential diagnosis for masses located in the head and face. Early and accurate diagnosis, followed by wide surgical excision, has a favorable prognosis. Therefore, clinicians should be familiar with the clinical and pathological features of this disease.
摘要：
未经授权：颌下腺皮脂腺癌（SC）极为罕见。由于低发病率和非特异性临床表现，诊断通常是延迟的，这增加了转移和死亡率。迄今为止,已报道5例颌下腺SC。这里,我们提出了一个新的案例，并回顾了相关的文献。
未经授权：一名36岁的妇女，左侧颌下腺增大。临床特征包括具有正常覆盖皮肤的非压痛孤立性结节肿块。除了左下颌下腺肿胀的肿块外，计算机断层扫描或超声检查没有特殊发现。患者接受了手术切除。病理检查证实SC伴神经浸润。该病例的免疫组织化学检查显示P63，P40，CK7，CK8/18，MLH1，MSH2，MSH6和PMS2阳性染色。样本雄激素受体阴性,CEA,S-100,CK5/6,SOX-10,SOX-11,SMA,和GCDFP-15。KI-67标记指数确定为15%。部分区域PAS和抗上皮膜抗原阳性。病人仍在接受随访,2个月无转移或复发。
UNASSIGNED:这个案例突出了一个事实，尽管它很少，SC应被视为头部和面部肿块的鉴别诊断。早期和准确的诊断，随后是广泛的手术切除，预后良好。因此,临床医师应熟悉本病的临床和病理特点。
未经授权：一名36岁的妇女，左侧颌下腺增大。
UNASSIGNED:这个案例突出了一个事实，尽管它很少，
