PDF(Pubmed)
Abstract：
Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging (MRI) guided radiotherapy (MRgRT) may hold the greatest potential to improve the therapeutic gains of image-guided delivery of radiation dose. The ability of the MRI linear accelerator (LINAC) to image tumors and organs with on-table MRI, to manage organ motion and dose delivery in real-time, and to adapt the radiotherapy plan on the day of treatment while the patient is on the table are major advances relative to current conventional radiation treatments. These advanced techniques demand efficient coordination and communication between members of the treatment team. MRgRT could fundamentally transform the radiotherapy delivery process within radiation oncology centers through the reorganization of the patient and treatment team workflow process. However, the MRgRT technology currently is limited by accessibility due to the cost of capital investment and the time and personnel allocation needed for each fractional treatment and the unclear clinical benefit compared to conventional radiotherapy platforms. As the technology evolves and becomes more widely available, we present the case that MRgRT has the potential to become a widely utilized treatment platform and transform the radiation oncology treatment process just as earlier disruptive radiation therapy technologies have done.
摘要：
放射治疗技术的进步已经实现了更精确的目标引导，改善治疗验证，和更大的控制和多功能性的辐射输送。在最近的新技术中，磁共振成像（MRI）引导的放射治疗（MRgRT）可能具有最大的潜力，以提高图像引导的辐射剂量递送的治疗增益。MRI直线加速器（LINAC）通过台式MRI对肿瘤和器官进行成像的能力，实时管理器官运动和剂量输送，和适应放疗计划的当天的治疗，而病人是在桌子上是主要的进步相对于目前的传统放射治疗。这些先进的技术需要治疗团队成员之间的有效协调和沟通。MRgRT可以通过患者和治疗团队工作流程的重组从根本上改变放射肿瘤中心内的放射治疗交付流程。然而,与常规放疗平台相比,MRgRT技术目前受到可及性的限制,原因是资本投资成本以及每次分次治疗所需的时间和人员分配以及临床获益不明确.随着技术的发展和普及，我们认为MRgRT有潜力成为广泛使用的治疗平台,并像早期的破坏性放射治疗技术一样改变肿瘤放射治疗过程.
