Abstract：
The objective of this meta-analysis is to evaluate the efficacy of Transversus Abdominis Plane Block (TAPB) in pain control and recovery after open hepatic surgery.
We searched for the articles in PubMed, Google Scholar, and the Cochrane Library published before March 2022. We included randomized controlled trials (RCTs) comparing TAPB with a placebo in adult patients after open liver surgery. Meta-analysis was conducted in RevMan 5.4. Methodological quality was assessed via the Jadad/Oxford scale and Cochrane Risk of Bias tool.
Five RCTs with 347 patients were included. All studies had an acceptable Jadad score or higher. For pain at rest at 24hours postoperatively, the standardized mean difference (SMD) with a 95% confidence interval (CI) was -1.08 [-1.97, -0.18], P-value 0.02, favoring TAPB. Models for total opioid consumption, nausea and vomiting, and duration of hospital stay did not demonstrate a difference between the groups. The model for time to first flatus favored TAPB with SMD with a 95% CI of -1.48 [-2.72, -0.24], P-value 0.02.
Our meta-analysis of five RCTs favored TAPB regarding pain control at rest and time to first flatus. Due to the small sample size and considerable heterogeneity, more RCTs are needed.
CRD42022320565.
We searched for the articles in PubMed, Google Scholar, and the Cochrane Library published before March 2022. We included randomized controlled trials (RCTs) comparing TAPB with a placebo in adult patients after open liver surgery. Meta-analysis was conducted in RevMan 5.4. Methodological quality was assessed via the Jadad/Oxford scale and Cochrane Risk of Bias tool.
Five RCTs with 347 patients were included. All studies had an acceptable Jadad score or higher. For pain at rest at 24hours postoperatively, the standardized mean difference (SMD) with a 95% confidence interval (CI) was -1.08 [-1.97, -0.18], P-value 0.02, favoring TAPB. Models for total opioid consumption, nausea and vomiting, and duration of hospital stay did not demonstrate a difference between the groups. The model for time to first flatus favored TAPB with SMD with a 95% CI of -1.48 [-2.72, -0.24], P-value 0.02.
Our meta-analysis of five RCTs favored TAPB regarding pain control at rest and time to first flatus. Due to the small sample size and considerable heterogeneity, more RCTs are needed.
CRD42022320565.
摘要：
目的：本荟萃分析的目的是评估腹横肌平面阻滞（TAPB）在开放肝脏手术后疼痛控制和恢复中的疗效。
方法：我们搜索了PubMed中的文章，谷歌学者，和Cochrane图书馆在2022年3月之前出版。我们纳入了随机对照试验（RCTs），比较TAPB与安慰剂在成年患者开放肝脏手术后。在RevMan5.4中进行Meta分析。通过Jadad/Oxford量表和Cochrane偏差风险工具评估方法学质量。
结果：纳入5个RCTs，347例患者。所有研究均具有可接受的Jadad评分或更高。对于术后24小时休息时的疼痛，具有95%置信区间(CI)的标准化平均差(SMD)为-1.08[-1.97,-0.18]，P值0.02，有利于TAPB。阿片类药物总消费量模型，恶心和呕吐，住院时间和两组间无差异.首次排气时间的模型倾向于具有SMD的TAPB，其95%CI为-1.48[-2.72，-0.24]，P值0.02。
结论：我们对5项RCT的荟萃分析在休息和首次排气时的疼痛控制方面支持TAPB。由于样本量小和相当大的异质性，需要更多的RCT。
背景：CRD42022320565.
方法：我们搜索了PubMed中的文章，
结果：纳入5个RCTs，347例患者。
结论：我们对5项RCT的荟萃分析在休息和首次排气时的疼痛控制方面支持TAPB。
背景：CRD42022320565.
