METHODS: This is a multicenter observational retrospective study conducted in patients with stage I and II UCSs.
RESULTS: Ninety-five women with histological diagnosis of early-stage UCSs were retrieved: 60 (63.2%) had tumors with homologous sarcomatous components, and 35 (36.8%) with heterologous. At univariate analysis, a stromal invasion ≥ 50%, the presence of clear cell, serous or undifferentiated carcinomatous component, the heterologous sarcomatous component and FIGO stage IB and II were shown to be variables with a statistically significant negative impact on PFS. Similarly, a depth of invasion ≥ 50%, the heterologous sarcomatous component and FIGO stage IB and II were statistically negative prognostic factors also concerning OS. At multivariate analysis, only the heterologous sarcomatous component was confirmed to be a statistically significant negative prognostic factor both on PFS (HR 2.362, 95% CI 1.207-4.623, p value = 0.012) and on OS (HR 1.950, 95% CI 1.032-3.684, p = 0.040).
CONCLUSIONS: Carcinomatous and sarcomatous components both played a role in tumor progression and patients\' survival. However, only the sarcomatous component retained a statistical significance at the multivariable model suggesting its preeminent prognostic role in early-stage UCSs.
方法:这是一项针对I期和II期UCSs患者进行的多中心观察性回顾性研究。
结果:检索到95例经组织学诊断为早期UCSs的妇女:60例(63.2%)肿瘤具有同源肉瘤成分,和35(36.8%)与异源。在单变量分析中,基质侵入≥50%,透明细胞的存在,浆液性或未分化的癌成分,异源肉瘤成分和FIGO阶段IB和II被证明是对PFS具有统计学显著负面影响的变量。同样,侵入深度≥50%,异源肉瘤成分和FIGOIB期和II期也是与OS相关的统计学阴性预后因素.在多变量分析中,在PFS(HR2.362,95%CI1.207-4.623,p值=0.012)和OS(HR1.950,95%CI1.032-3.684,p=0.040)上,只有异源肉瘤成分被证实是统计学上显著的阴性预后因素.
结论:癌性和肉瘤性成分均在肿瘤进展和患者生存中起作用。然而,在多变量模型中,只有肉瘤成分保留了统计学意义,提示其在早期UCSs中具有突出的预后作用.