Abstract：
Breast cancer incidence and mortality rates have increased exponentially during the last decade, particularly among female patients. Current therapies, including surgery and chemotherapy, have significant negative physical and mental impacts on patients. As a safer alternative, gene therapy utilising a therapeutic gene with the potential to treat various ailments is being considered. Delivery of the gene generally utilises viral vectors. However, immunological reactions and even mortality have been recorded as side effects. As a result, non-viral vectors, such as liposomes, a system composed of lipid bilayers formed into nanoparticles, are being studied. Liposomes have demonstrated tremendous potential due to their limitless ability to combine many functions into a system with desirable characteristics and functionality. This article discusses cationic, anionic, and neutral liposomes with their stability, cytotoxicity, transfection ability, cellular uptake, and limitation as a gene carrier suitable for gene therapy specifically for cancer. Due to the more practical approach of employing electrostatic contact with the negatively charged nucleic acid and the cell membrane for absorption purposes, cationic liposomes appear to be more suited for formulation for gene delivery and therapy for breast cancer treatment. As the other alternatives have numerous complicated additional modifications, attachments need to be made to achieve a functional gene therapy system for breast cancer treatment, which were also discussed in this review. This review aimed to increase understanding and build a viable breast cancer gene therapy treatment strategy.
摘要：
在过去的十年中，乳腺癌的发病率和死亡率呈指数增长，尤其是女性患者。目前的疗法,包括手术和化疗,对患者的身体和精神有显著的负面影响。作为一种更安全的选择,正在考虑利用具有治疗各种疾病潜力的治疗基因进行基因治疗。基因的递送通常利用病毒载体。然而,免疫反应甚至死亡率已被记录为副作用。因此,非病毒载体，如脂质体，由形成纳米颗粒的脂质双层组成的系统，正在研究。脂质体由于其将许多功能结合到具有所需特性和功能的系统中的无限能力而显示出巨大的潜力。本文讨论了阳离子，阴离子，和具有稳定性的中性脂质体，细胞毒性，转染能力，细胞摄取，和限制作为基因载体适用于基因疗法特别是癌症。由于采用与带负电荷的核酸和细胞膜的静电接触用于吸收目的的更实际的方法，阳离子脂质体似乎更适合用于基因递送和乳腺癌治疗的治疗。由于其他替代方案有许多复杂的额外修改，为了实现乳腺癌治疗的功能性基因治疗系统，这也在这篇综述中进行了讨论。本文旨在提高对乳腺癌基因治疗的认识，建立可行的乳腺癌基因治疗治疗策略。
