Abstract：
The success of a prosthetic treatment is closely related to the periodontal health of the individual. The aim of this article was to review and present the importance of prosthetic restorative materials on the condition of the periodontium, the changes that occur in the composition of the subgingival microbiota and the levels of inflammatory markers in gingival crevicular fluid. Articles on the influence of different prosthetic restorative materials on subgingival microbiota and proinflammatory cytokines were searched for using the keywords \"prosthetic biomaterials\", \"fixed prosthesis\", \"periodontal health\", \"subgingival microbiota\", \"periodontal biomarkers\" and \"gingival crevicular fluid\" in PubMed/Medline, Science Direct, Scopus and Google Scholar. The type of material used for prosthesis fabrication together with poor marginal and internal fit can result in changes in the composition of the subgingival microbiota, as well as increased accumulation and retention of dentobacterial plaque, thus favoring the development of periodontal disease and prosthetic treatment failure. Biological markers have helped to understand the inflammatory response of different prosthetic materials on periodontal tissues with the main purpose of improving their clinical application in patients who need them. Metal-free ceramic prostheses induce a lower inflammatory response regardless of the fabrication method; however, the use of CAD/CAM systems is recommended for their fabrication. In addition, it is presumed that metal-ceramic prostheses cause changes in the composition of the subgingival microbiota producing a more dysbiotic biofilm with a higher prevalence of periodontopathogenic bacteria, which may further favor periodontal deterioration.
摘要：
假体治疗的成功与个体的牙周健康密切相关。本文的目的是回顾和介绍修复材料对牙周组织状况的重要性，牙龈下微生物群组成和龈沟液中炎症标志物水平的变化。使用关键词“假体生物材料”搜索有关不同假体修复材料对龈下微生物群和促炎细胞因子影响的文章，“固定假体”，“牙周健康”，“牙龈下微生物群”，PubMed/Medline中的“牙周生物标志物”和“龈沟液”，科学直接，Scopus和谷歌学者。用于假体制造的材料类型以及较差的边缘和内部配合可导致龈下微生物群组成的变化，以及增加的细菌菌斑的积累和保留，从而有利于牙周病的发展和修复治疗失败。生物学标记物有助于了解不同假体材料对牙周组织的炎症反应，主要目的是提高其在有需要的患者中的临床应用。无金属陶瓷假体诱导较低的炎症反应，无论制造方法;然而，建议使用CAD/CAM系统进行制造。此外,据推测，金属-陶瓷假体会导致牙龈下微生物群的组成发生变化，从而产生更多的生物失调生物膜，牙周病原细菌的患病率更高，这可能进一步有利于牙周恶化。
