Abstract：
While adoption of machine perfusion technologies into clinical practice in the United States has been much slower than in Europe, recent changes in the transplant landscape as well as device availability following FDA approval have paved the way for rapid growth. Machine perfusion may provide one mechanism to maximize the utilization of potential donor liver grafts. Indeed, multiple studies have shown increased organ utilization with the implementation of technologies such as ex-situ normothermic machine perfusion (NMP), ex-situ hypothermic machine perfusion (HMP) and in-situ normothermic regional perfusion (NRP). The current review describes the history and development of machine perfusion utilization in the Unites States along with future directions. It also describes the differences in landscape between Europe and the United States and how this has shaped clinical application of these technologies.
摘要：
虽然在美国，机器灌注技术在临床实践中的采用比欧洲慢得多，FDA批准后，移植景观以及设备可用性的最新变化为快速增长铺平了道路。机器灌注可以提供一种机制来最大化潜在供体肝移植物的利用。的确,多项研究表明，随着技术的实施，器官利用率增加，例如非原位常温机器灌注（NMP），异位低温机器灌注（HMP）和原位常温区域灌注（NRP）。当前的评论描述了美国机器灌注利用的历史和发展以及未来的方向。它还描述了欧洲和美国之间的景观差异，以及这如何影响这些技术的临床应用。
