PDF(Pubmed)
Abstract：
Pancreatic cancer is one of the most malignant cancer types and has a poor prognosis. It is often diagnosed at an advanced stage because of the absence of typical symptoms. Therefore, it is necessary to establish a screening method for the early detection of pancreatic cancer in high-risk individuals. This is a prospective validation study conducted in a cohort of 1033 Japanese individuals (male, n = 467, age = 63.3 ± 11.5 years; female, n = 566, age = 64.2 ± 10.6 years) to evaluate the use of salivary polyamines for screening pancreatic diseases and cancers. Patients with pancreatic cancer were not included; however, other pancreatic diseases were treated as positive cases for accuracy verification. Of the 135 individuals with elevated salivary polyamine markers, 66 had pancreatic diseases, such as chronic pancreatitis and pancreatic cysts, and 1 had gallbladder cancer. These results suggest that the salivary polyamine panel is a useful noninvasive pancreatic disease screening tool.
摘要：
胰腺癌是最恶性的癌症类型之一，预后较差。由于没有典型症状，通常在晚期诊断。因此,有必要建立一种在高危人群中早期发现胰腺癌的筛查方法。这是一项前瞻性验证研究，在1033名日本人(男性，n=467，年龄=63.3±11.5岁；女性，n=566，年龄=64.2±10.6岁），以评估唾液多胺在筛查胰腺疾病和癌症中的应用。胰腺癌患者不包括在内；然而，其他胰腺疾病被视为阳性病例，以进行准确性验证。135名唾液多胺标志物升高的个体中,66人患有胰腺疾病，比如慢性胰腺炎和胰腺囊肿，1人患有胆囊癌。这些结果表明，唾液多胺小组是一种有用的非侵入性胰腺疾病筛查工具。
