Abstract：
Regeneration of damaged peripheral nerves remains one of the main challenges of neurosurgery and regenerative medicine, a nerve functionality is rarely restored, especially after severe injuries. Researchers are constantly looking for innovative strategies for tackling this problem, with the development of advanced tissue-engineered nerve conduits and new pharmacological and physical interventions, with the aim of improving patients\' life quality. Different evaluation methods can be used to study the effectiveness of a new treatment, including functional tests, morphological assessment of regenerated nerve fibers and biomolecular analyses of key factors necessary for good regeneration. The number and diversity of protocols and methods, as well as the availability of innovative technologies which are used to assess nerve regeneration after experimental interventions, often makes it difficult to compare results obtained in different labs. The purpose of the current review is to describe the main morphological approaches used to evaluate the degree of nerve fiber regeneration in terms of their usefulness and limitations.
摘要：
受损周围神经的再生仍然是神经外科和再生医学的主要挑战之一。神经的功能很少恢复，尤其是严重受伤后。研究人员一直在寻找创新的策略来解决这个问题，随着先进的组织工程神经导管和新的药物和物理干预的发展，目的是提高患者的生活质量。可以使用不同的评估方法来研究新治疗方法的有效性，包括功能测试，再生神经纤维的形态学评估和良好再生所必需的关键因素的生物分子分析。协议和方法的数量和多样性，以及用于评估实验干预后神经再生的创新技术的可用性，通常很难比较不同实验室的结果。本综述的目的是描述用于评估神经纤维再生程度的主要形态学方法的有用性和局限性。
