Abstract：
Drug-resistant bacteria are one of the main reasons of deaths worldwide. One of the significant groups of these bacteria are carbapenemase-producing Enterobacteriaceae (CPE). The goal of this cross-sectional study was the identification and hierarchisation of selected risk factors of CPE colonisation. To achieve that goal, we examined 236 patients for the presence of CPE using the standard method of anal swabs. The patients were divided into three groups: hospitalised patients; those chronically dialysed; those requiring home care. A very thorough medical interview was conducted for comorbidities. A statistical analysis relationship between comorbidities and locations of the patient\'s stay with the positive result of the culture was investigated. A significant relationship was demonstrated between the positive result of the culture and confirmed dementia, heart failure, connective tissue diseases, and established irregularities in the level of leukocytes. No significant relationship was demonstrated with the remaining comorbidities considered in the study. Afterwards these factors were compared for importance for the assessment of risk of a positive swab result-the biggest importance was found in establishing connective tissue disease. Next were dementia, abnormal values of leukocytes, heart failure, and at the end, stay at the orthopaedics ward. Conclusions: The study identified asymptomatic carriers of CPE, which demonstrates the need for further studies in order to identify infection risk factors. The connective tissue diseases are the most important variable which enable the prediction of CPE colonisation-the next ones are dementia, abnormal values of leukocytes, heart failure, and stay at the orthopaedics ward.
摘要：
耐药细菌是全球范围内死亡的主要原因之一。这些细菌的重要群体之一是产生碳青霉烯酶的肠杆菌科(CPE)。这项横断面研究的目的是鉴定和分层选择的CPE定植危险因素。为了实现这个目标,我们使用标准的肛门拭子方法检查了236例患者是否存在CPE.患者分为三组：住院患者；长期透析的患者；需要家庭护理的患者。对合并症进行了非常彻底的医学访谈。研究了合并症和患者住院地点与培养阳性结果之间的统计分析关系。培养的阳性结果与确诊的痴呆症之间存在显着关系，心力衰竭,结缔组织疾病,并建立了白细胞水平的不规则性。与研究中考虑的其余合并症没有显着关系。之后，比较了这些因素对评估阳性拭子结果风险的重要性，发现最大的重要性在于建立结缔组织疾病。接下来是痴呆症，白细胞的异常值，心力衰竭,最后，待在骨科病房.结论：该研究确定了无症状的CPE携带者，这表明需要进一步研究以确定感染危险因素。结缔组织疾病是能够预测CPE定植的最重要的变量，其次是痴呆，白细胞的异常值，心力衰竭,待在骨科病房.
