Abstract：
Tumor microenvironment (TME) is the immediate environment where cancer cells reside in a tumor. It is composed of multiple cell types and extracellular matrix. Microenvironments can be restrictive or conducive to the progression of cancer cells. Initially, microenvironments are suppressive in nature. Stepwise accumulation of mutations in oncogenes and tumor suppressor genes enables cancer cells to acquire the ability to reshape the microenvironment to advance their growth and metastasis. Among the many genetic events, the loss-of-function mutations in tumor suppressor genes play a pivotal role. In this review, we will discuss the changes in TME and the ramifications on metastasis upon altered expression of tumor metastasis suppressor gene RKIP in breast cancer cells.
摘要：
肿瘤微环境(TME)是癌细胞驻留在肿瘤中的直接环境。它由多种细胞类型和细胞外基质组成。微环境可以是限制性的或有助于癌细胞的进展。最初，微环境在本质上是压抑的。癌基因和肿瘤抑制基因中突变的逐步积累使癌细胞能够获得重塑微环境以促进其生长和转移的能力。在许多遗传事件中，抑癌基因的功能缺失突变起着关键作用.在这次审查中,我们将讨论TME的变化以及肿瘤转移抑制基因RKIP在乳腺癌细胞中表达改变对转移的影响。
