UNASSIGNED: In this study, 80 participants scheduled for UVATS will be randomly allocated to the bilateral sequential TPVB group (G2) and the control group (G1). The patient of G2 will be performed bilateral TPVB at 2 time-points: before the start of the first side of pulmonary resection and before the start of the contralateral pulmonary resection. G1 will only receive standard analgesia protocol. The primary outcome is the numeric rating scale score during coughing at 24 h postoperatively. The secondary outcomes include the Prince Henry Pain Score scores, sufentanil consumption, postoperative nausea and vomiting, levels of inflammatory factors, and the Quality of Recovery-40 scores at different time points, as well as chronic pain at postoperative day (POD) 90.
UNASSIGNED: This is the first prospective trial to determine the safety and effectiveness of ultrasound-guided bilateral sequential TPVB for postoperative analgesia following simultaneous bilateral UVATS. This study also intended to evaluate the effect of this intervention on postoperative quality of recovery and inflammation levels. The final results will provide clinical evidence related to bilateral sequential TPVB, and promote the application of that acting as a more appropriate analgesic method for simultaneous bilateral UVATS.
未经批准:在这项研究中,计划参加UVATS的80名参与者将被随机分配到双边序贯TPVB组(G2)和对照组(G1)。G2患者将在2个时间点进行双侧TPVB:在肺切除术的第一侧开始之前和对侧肺切除术开始之前。G1将只接受标准的镇痛方案。主要结果是术后24小时咳嗽期间的数字评定量表得分。次要结果包括亨利王子疼痛评分,舒芬太尼消费,术后恶心呕吐,炎症因子水平,以及不同时间点的恢复质量-40评分,以及术后当天的慢性疼痛(POD)90。
UNASSIGNED:这是第一个前瞻性试验,旨在确定超声引导的双侧序贯TPVB用于同时双侧UVATS术后镇痛的安全性和有效性。这项研究还旨在评估这种干预措施对术后恢复质量和炎症水平的影响。最终结果将提供与双侧序贯TPVB相关的临床证据,并促进其作为更合适的同时双侧UVATS镇痛方法的应用。