PDF(Pubmed)
Abstract：
UNASSIGNED: Simultaneous bilateral pulmonary resection via uniportal video-assisted thoracoscopic surgery (UVATS) was safe and feasible for the treatment of bilateral multiple pulmonary nodules. But, it should be noted that considerable postoperative pain at the bilateral surgical site was a crucial issue. The safety and efficacy of bilateral thoracic paravertebral block (TPVB) have been reported for postoperative analgesia. But, whether bilateral sequential TPVB can be safely and effectively used in simultaneous bilateral UVATS remains unknown. Therefore, this study aimed to determine the analgesic efficacy and safety of bilateral sequential TPVB after simultaneous bilateral UVATS.
UNASSIGNED: In this study, 80 participants scheduled for UVATS will be randomly allocated to the bilateral sequential TPVB group (G2) and the control group (G1). The patient of G2 will be performed bilateral TPVB at 2 time-points: before the start of the first side of pulmonary resection and before the start of the contralateral pulmonary resection. G1 will only receive standard analgesia protocol. The primary outcome is the numeric rating scale score during coughing at 24 h postoperatively. The secondary outcomes include the Prince Henry Pain Score scores, sufentanil consumption, postoperative nausea and vomiting, levels of inflammatory factors, and the Quality of Recovery-40 scores at different time points, as well as chronic pain at postoperative day (POD) 90.
UNASSIGNED: This is the first prospective trial to determine the safety and effectiveness of ultrasound-guided bilateral sequential TPVB for postoperative analgesia following simultaneous bilateral UVATS. This study also intended to evaluate the effect of this intervention on postoperative quality of recovery and inflammation levels. The final results will provide clinical evidence related to bilateral sequential TPVB, and promote the application of that acting as a more appropriate analgesic method for simultaneous bilateral UVATS.
UNASSIGNED: In this study, 80 participants scheduled for UVATS will be randomly allocated to the bilateral sequential TPVB group (G2) and the control group (G1). The patient of G2 will be performed bilateral TPVB at 2 time-points: before the start of the first side of pulmonary resection and before the start of the contralateral pulmonary resection. G1 will only receive standard analgesia protocol. The primary outcome is the numeric rating scale score during coughing at 24 h postoperatively. The secondary outcomes include the Prince Henry Pain Score scores, sufentanil consumption, postoperative nausea and vomiting, levels of inflammatory factors, and the Quality of Recovery-40 scores at different time points, as well as chronic pain at postoperative day (POD) 90.
UNASSIGNED: This is the first prospective trial to determine the safety and effectiveness of ultrasound-guided bilateral sequential TPVB for postoperative analgesia following simultaneous bilateral UVATS. This study also intended to evaluate the effect of this intervention on postoperative quality of recovery and inflammation levels. The final results will provide clinical evidence related to bilateral sequential TPVB, and promote the application of that acting as a more appropriate analgesic method for simultaneous bilateral UVATS.
摘要：
UNASSIGNED：通过单孔电视辅助胸腔镜手术（UVATS）同时进行双侧肺切除术对于治疗双侧多发肺结节是安全可行的。但是,应当指出,双侧手术部位的相当大的术后疼痛是一个关键问题.已报道双侧胸椎旁神经阻滞（TPVB）用于术后镇痛的安全性和有效性。但是,双侧序贯TPVB是否可以安全有效地用于同时进行的双侧UVATS尚不清楚.因此,本研究旨在确定同时进行双侧UVATS后,双侧序贯TPVB的镇痛疗效和安全性.
未经批准：在这项研究中，计划参加UVATS的80名参与者将被随机分配到双边序贯TPVB组（G2）和对照组（G1）。G2患者将在2个时间点进行双侧TPVB：在肺切除术的第一侧开始之前和对侧肺切除术开始之前。G1将只接受标准的镇痛方案。主要结果是术后24小时咳嗽期间的数字评定量表得分。次要结果包括亨利王子疼痛评分，舒芬太尼消费，术后恶心呕吐,炎症因子水平，以及不同时间点的恢复质量-40评分，以及术后当天的慢性疼痛（POD）90。
UNASSIGNED：这是第一个前瞻性试验，旨在确定超声引导的双侧序贯TPVB用于同时双侧UVATS术后镇痛的安全性和有效性。这项研究还旨在评估这种干预措施对术后恢复质量和炎症水平的影响。最终结果将提供与双侧序贯TPVB相关的临床证据，并促进其作为更合适的同时双侧UVATS镇痛方法的应用。
未经批准：在这项研究中，计划参加UVATS的80名参与者将被随机分配到双边序贯TPVB组（G2）和对照组（G1）。G2患者将在2个时间点进行双侧TPVB：在肺切除术的第一侧开始之前和对侧肺切除术开始之前。G1将只接受标准的镇痛方案。主要结果是术后24小时咳嗽期间的数字评定量表得分。次要结果包括亨利王子疼痛评分，舒芬太尼消费，术后恶心呕吐,炎症因子水平，以及不同时间点的恢复质量-40评分，以及术后当天的慢性疼痛（POD）90。
UNASSIGNED：这是第一个前瞻性试验，旨在确定超声引导的双侧序贯TPVB用于同时双侧UVATS术后镇痛的安全性和有效性。这项研究还旨在评估这种干预措施对术后恢复质量和炎症水平的影响。最终结果将提供与双侧序贯TPVB相关的临床证据，并促进其作为更合适的同时双侧UVATS镇痛方法的应用。
