PDF(Pubmed)
Abstract：
UNASSIGNED: Several analgesics have been applied under various protocols to control the moderate-to-severe postoperative pain caused by the surgical extraction of an impacted mandibular third molar. However, a consensus on optimal pain management while minimizing side effects is yet to be reached.
UNASSIGNED: This multi-center, prospective, double-blind, randomized controlled trial aims to evaluate the efficacy and safety of sequential multimodal analgesia combined with postoperative zaltoprofen along with multiple preemptive analgesics. A total of 80 participants with bilateral impacted mandibular third molar from two hospitals were randomized into two groups. Two surgical extractions were performed at one-month intervals, and in a crossover design, celecoxib or tramadol/acetaminophen was administered before one extraction and placebo before the other extraction. Following extraction, all subjects took zaltoprofen for 5 days. The outcome measures included pain at specific times, time and intensity of the first pain onset after extraction, need of rescue drugs, and occurrence and frequency of side effects.
UNASSIGNED: This ongoing clinical trial was designed to provide evidence regarding a new protocol for effective postoperative pain management of a commonly performed surgical extraction. The results of this study will provide guidance to clinicians regarding the timing and combination of oral analgesics in various oral surgeries performed under local anesthesia.
UNASSIGNED: KCT0005450, registered on October 7, 2020.
UNASSIGNED: This multi-center, prospective, double-blind, randomized controlled trial aims to evaluate the efficacy and safety of sequential multimodal analgesia combined with postoperative zaltoprofen along with multiple preemptive analgesics. A total of 80 participants with bilateral impacted mandibular third molar from two hospitals were randomized into two groups. Two surgical extractions were performed at one-month intervals, and in a crossover design, celecoxib or tramadol/acetaminophen was administered before one extraction and placebo before the other extraction. Following extraction, all subjects took zaltoprofen for 5 days. The outcome measures included pain at specific times, time and intensity of the first pain onset after extraction, need of rescue drugs, and occurrence and frequency of side effects.
UNASSIGNED: This ongoing clinical trial was designed to provide evidence regarding a new protocol for effective postoperative pain management of a commonly performed surgical extraction. The results of this study will provide guidance to clinicians regarding the timing and combination of oral analgesics in various oral surgeries performed under local anesthesia.
UNASSIGNED: KCT0005450, registered on October 7, 2020.
摘要：
UNASSIGNED：已经在各种方案下应用了几种镇痛药，以控制由下颌阻生第三磨牙手术拔除引起的中度至重度术后疼痛。然而,关于最佳疼痛管理同时尽量减少副作用的共识尚未达成.
未经评估：这个多中心，prospective,双盲,随机对照试验旨在评价序贯多模式镇痛联合扎托洛芬术后多种超前镇痛的疗效和安全性。来自两家医院的80名双侧下颌第三磨牙患者被随机分为两组。每隔一个月进行两次手术拔除，在交叉设计中，塞来昔布或曲马多/对乙酰氨基酚在一次提取前给药，安慰剂在另一次提取前给药。提取后,所有受试者服用扎托洛芬5天。结果测量包括特定时间的疼痛，拔牙后第一次疼痛发作的时间和强度，需要救援药物，以及副作用的发生和频率。
UNASSIGNED：这项正在进行的临床试验旨在提供有关新方案的证据，该方案用于对通常进行的手术摘除术进行有效的术后疼痛管理。这项研究的结果将为临床医生提供有关在局部麻醉下进行的各种口腔手术中口服镇痛药的时机和组合的指导。
UNASSIGNED：KCT0005450，于2020年10月7日注册。
未经评估：这个多中心，prospective,双盲,随机对照试验旨在评价序贯多模式镇痛联合扎托洛芬术后多种超前镇痛的疗效和安全性。来自两家医院的80名双侧下颌第三磨牙患者被随机分为两组。每隔一个月进行两次手术拔除，在交叉设计中，塞来昔布或曲马多/对乙酰氨基酚在一次提取前给药，安慰剂在另一次提取前给药。提取后,所有受试者服用扎托洛芬5天。结果测量包括特定时间的疼痛，拔牙后第一次疼痛发作的时间和强度，需要救援药物，以及副作用的发生和频率。
UNASSIGNED：这项正在进行的临床试验旨在提供有关新方案的证据，该方案用于对通常进行的手术摘除术进行有效的术后疼痛管理。这项研究的结果将为临床医生提供有关在局部麻醉下进行的各种口腔手术中口服镇痛药的时机和组合的指导。
UNASSIGNED：KCT0005450，于2020年10月7日注册。
