PDF(Pubmed)
Abstract：
UNASSIGNED: Uric acid to high-density lipoprotein cholesterol ratio (UHR), the ratio of uric acid to high-density lipoprotein cholesterol, is a newly proposed marker of metabolic abnormalities. There are few previous studies directly investigating the relationship between UHR and alanine aminotransferase (ALT), especially in short stature populations, however, short stature children and adolescents are more likely to have metabolic disorders. This research aimed to investigate the relationship between the UHR and ALT in children and adolescents with short stature.
UNASSIGNED: In this cross-sectional analysis, the clinical data of 1,510 children with height below -2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from 1 March 2013 to 31 December 2021, were selected. Anthropometric and biochemical indicators were measured. The relationship between UHR and ALT was analysed.
UNASSIGNED: The univariate analysis results showed that UHR was positively associated with ALT (β = 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors, a non-linear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β = 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229).
UNASSIGNED: Our study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.
UNASSIGNED: In this cross-sectional analysis, the clinical data of 1,510 children with height below -2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from 1 March 2013 to 31 December 2021, were selected. Anthropometric and biochemical indicators were measured. The relationship between UHR and ALT was analysed.
UNASSIGNED: The univariate analysis results showed that UHR was positively associated with ALT (β = 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors, a non-linear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β = 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229).
UNASSIGNED: Our study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.
摘要：
未经评估：尿酸与高密度脂蛋白胆固醇的比率（UHR），尿酸与高密度脂蛋白胆固醇的比例，是新提出的代谢异常的标志。以前的研究很少直接调查UHR和丙氨酸转氨酶（ALT）之间的关系，尤其是在身材矮小的人群中，然而,身材矮小的儿童和青少年更容易有代谢紊乱。本研究旨在探讨身材矮小的儿童和青少年的UHR与ALT之间的关系。
未经评估：在此横截面分析中，在内分泌科评估的1,510名身高低于-2SD的儿童的临床数据，选择2013年3月1日至2021年12月31日济宁医学院附属医院。测量人体测量和生化指标。分析UHR与ALT的关系。
UNASSIGNED：单因素分析结果显示，UHR与ALT呈正相关（β=0.43，P<0.0001）。此外，在调整了可能的混杂因素后，通过平滑曲线拟合检测到UHR和ALT之间的非线性关系，多元分段线性回归分析后，UHR的拐点为10.93％。当UHR大于10.93％时，ALT随UHR升高而升高（β=0.69，95％CI0.39，0.98；P<0.0001）。然而,当UHR小于10.93%时，我们没有观察到显著的相关性(P=0.9229)。
未经评估：我们的研究表明，在中国身材矮小的儿童和青少年中，UHR可能与ALT水平的调节有关，这种关系值得进一步调查。
未经评估：在此横截面分析中，在内分泌科评估的1,510名身高低于-2SD的儿童的临床数据，选择2013年3月1日至2021年12月31日济宁医学院附属医院。测量人体测量和生化指标。分析UHR与ALT的关系。
UNASSIGNED：单因素分析结果显示，UHR与ALT呈正相关（β=0.43，P<0.0001）。此外，在调整了可能的混杂因素后，通过平滑曲线拟合检测到UHR和ALT之间的非线性关系，多元分段线性回归分析后，UHR的拐点为10.93％。当UHR大于10.93％时，ALT随UHR升高而升高（β=0.69，95％CI0.39，0.98；P<0.0001）。然而,当UHR小于10.93%时，我们没有观察到显著的相关性(P=0.9229)。
未经评估：我们的研究表明，在中国身材矮小的儿童和青少年中，UHR可能与ALT水平的调节有关，这种关系值得进一步调查。
