PDF(Pubmed)
Abstract：
This study examined the effects of a combination corticosteroid plus long-acting beta2 -adrenergic agonist inhaler (IC) on rabbit phonation.
White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure (PTP; cmH2 O) and flow (PTF; L/min) were quantified.
Repeated measures analysis of variance indicated significant differences between the experimental and control groups (p < 0.05). Mean PTP and PTF values were higher (worse) for rabbits that received Advair HFA™.
Following 8-week exposure to ICs, rabbit larynges required greater air pressure and flow to initiate phonation. Because even modest phonation onset differences can have a meaningful clinical impact on voice function, these findings suggest that LABA ICs may put patients at risk for voice disorders. Furthermore, these voice disorders may occur within a relatively short timeframe. The results from this study have important clinical implications for voice care in those who use ICs.
NA Laryngoscope, 133:2680-2686, 2023.
White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure (PTP; cmH2 O) and flow (PTF; L/min) were quantified.
Repeated measures analysis of variance indicated significant differences between the experimental and control groups (p < 0.05). Mean PTP and PTF values were higher (worse) for rabbits that received Advair HFA™.
Following 8-week exposure to ICs, rabbit larynges required greater air pressure and flow to initiate phonation. Because even modest phonation onset differences can have a meaningful clinical impact on voice function, these findings suggest that LABA ICs may put patients at risk for voice disorders. Furthermore, these voice disorders may occur within a relatively short timeframe. The results from this study have important clinical implications for voice care in those who use ICs.
NA Laryngoscope, 133:2680-2686, 2023.
摘要：
目的：本研究检查了皮质类固醇和长效β2-肾上腺素能激动剂吸入剂（IC）的组合对兔发声的影响。
方法：新西兰白兔随机分为实验组和对照组（每组11只）。实验组通过带有单向阀和垫片的兽医面罩接受每日两次剂量的AdvairHFA™（丙酸氟替卡松45mcg和沙美特罗21mcg）；对照组接受雾化盐水。8周后,动物被安乐死，喉切除,冷冻,随后解冻并安装在标准的工作台设备上。在15次连续试验中引发了录音，并对发声阈值压力（PTP；cmH2O）和流量（PTF；L/min）进行了定量。
结果：重复测量方差分析表明实验组和对照组之间存在显着差异（p<0.05）。对于接受AdvairHFA™的兔,平均PTP和PTF值更高(更差)。
结论：在接触IC8周后，兔喉需要更大的气压和流量来启动发声。因为即使是适度的发声开始差异也可以对语音功能产生有意义的临床影响，这些研究结果表明,LABAIC可能使患者面临语音障碍的风险.此外，这些语音障碍可能在相对较短的时间内发生。这项研究的结果对使用IC的患者的语音护理具有重要的临床意义。
方法：N/A喉镜，2023年。
方法：新西兰白兔随机分为实验组和对照组（每组11只）。实验组通过带有单向阀和垫片的兽医面罩接受每日两次剂量的AdvairHFA™（丙酸氟替卡松45mcg和沙美特罗21mcg）；对照组接受雾化盐水。8周后,动物被安乐死，喉切除,冷冻,随后解冻并安装在标准的工作台设备上。在15次连续试验中引发了录音，并对发声阈值压力（PTP；cmH2O）和流量（PTF；L/min）进行了定量。
结果：重复测量方差分析表明实验组和对照组之间存在显着差异（p<0.05）。对于接受AdvairHFA™的兔,平均PTP和PTF值更高(更差)。
结论：在接触IC8周后，兔喉需要更大的气压和流量来启动发声。因为即使是适度的发声开始差异也可以对语音功能产生有意义的临床影响，这些研究结果表明,LABAIC可能使患者面临语音障碍的风险.此外，这些语音障碍可能在相对较短的时间内发生。这项研究的结果对使用IC的患者的语音护理具有重要的临床意义。
方法：N/A喉镜，2023年。
