Abstract：
BACKGROUND: Ondansetron is an antiemetic drug that is useful not only for prevention but also for the treatment of postoperative nausea and vomiting (PONV). We report a rare case of drowsiness in a child after using ondansetron for nausea on the day after general anesthesia.
METHODS: A 5-year-old boy underwent circumcision under general anesthesia and suffered from postoperative nausea and vomiting. He was administered 0.1mg/kg of ondansetron in the PACU and 23 h later on the day after surgery. After the second dose, he acutely exhibited drowsiness which resolved in 3 h. He was discharged to home later on the same day. He was not given any other drugs at the time, and the drowsiness was thought to be directly attributable to ondansetron, though the exact mechanism was unknown.
CONCLUSIONS: When drowsiness or other cognitive symptoms are observed after administration of ondansetron, it must be considered and managed as a possible side effect.
METHODS: A 5-year-old boy underwent circumcision under general anesthesia and suffered from postoperative nausea and vomiting. He was administered 0.1mg/kg of ondansetron in the PACU and 23 h later on the day after surgery. After the second dose, he acutely exhibited drowsiness which resolved in 3 h. He was discharged to home later on the same day. He was not given any other drugs at the time, and the drowsiness was thought to be directly attributable to ondansetron, though the exact mechanism was unknown.
CONCLUSIONS: When drowsiness or other cognitive symptoms are observed after administration of ondansetron, it must be considered and managed as a possible side effect.
摘要：
背景：昂丹司琼是一种止吐药，不仅可用于预防，还可用于治疗术后恶心和呕吐（PONV）。我们报告了一例罕见的儿童在全身麻醉后使用昂丹司琼治疗恶心后出现嗜睡的病例。
方法：一名5岁男童在全身麻醉下进行包皮环切术，术后出现恶心呕吐。他在PACU中和手术后第23小时后给予0.1mg/kg的昂丹司琼。第二次给药后,他敏锐地表现出困倦，并在3小时内解决。他在同一天晚些时候出院回家。当时他没有服用任何其他药物，困倦被认为直接归因于昂丹司琼，虽然确切的机制是未知的。
结论：当服用昂丹司琼后观察到嗜睡或其他认知症状时，必须将其视为可能的副作用。
方法：一名5岁男童在全身麻醉下进行包皮环切术，术后出现恶心呕吐。他在PACU中和手术后第23小时后给予0.1mg/kg的昂丹司琼。第二次给药后,他敏锐地表现出困倦，并在3小时内解决。他在同一天晚些时候出院回家。当时他没有服用任何其他药物，困倦被认为直接归因于昂丹司琼，虽然确切的机制是未知的。
结论：当服用昂丹司琼后观察到嗜睡或其他认知症状时，必须将其视为可能的副作用。
