Abstract：
The aim of the study was to examine the association between Life\'s Essential 8 (LE8) and the risk of cardiovascular and all-cause mortality.
The LE8 was computed for 1662 men, aged 42-60 years, without pre-existing history of cardiovascular disease (CVD) at baseline in the Kuopio Ischaemic Heart Disease study. The LE8 factors include diet, physical activity, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and lipids. Each LE8 factor was scored between 0 and 100 points. The summation of all points generated the total LE8 score, which was categorized into quartiles ≤-420, >420-485, >485-550, and >550. Multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals of LE8 scores for the outcomes. During a median follow-up of 30 years, 402 and 987 men died from CVD and any cause, respectively. The total LE8 score among participants ranged from 185 to 750. The higher the LE8 scores, the lower the risk of dying from CVD and all-cause. Following adjustment for age, alcohol consumption, and socio-economic status, every 50-unit increase in LE8 score was associated with 17% and 14% lower risk of CVD and all-cause deaths, respectively. Men within LE8 top quartile had 60% lower risk of CVD mortality when compared with those within the bottom quartile.
Life\'s Essential 8 was strongly and inversely associated with the risk of CVD death and all-cause mortality among ageing men. Measures that promote optimal LE8 scores should be encouraged among the general population.
The association between the American Heart Association’s Life’s Essential 8 (LE8) and the risk of cardiovascular and all-cause mortality was examined using the Kuopio Ischaemic Heart Disease Risk Factor Study in Finland. The result supports continuous improvement in healthy behaviours and factors used in generating LE8 score, which may lower future risk of dying from heart disease. In this paper: • Men who had total LE8 score more than 550 had lower risk of dying from heart disease or any cause of death compared with those with LE8 score ≤ 420. • Increasing LE8 score by 50 can lower risk of dying from heart disease or any other cause.
The LE8 was computed for 1662 men, aged 42-60 years, without pre-existing history of cardiovascular disease (CVD) at baseline in the Kuopio Ischaemic Heart Disease study. The LE8 factors include diet, physical activity, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and lipids. Each LE8 factor was scored between 0 and 100 points. The summation of all points generated the total LE8 score, which was categorized into quartiles ≤-420, >420-485, >485-550, and >550. Multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals of LE8 scores for the outcomes. During a median follow-up of 30 years, 402 and 987 men died from CVD and any cause, respectively. The total LE8 score among participants ranged from 185 to 750. The higher the LE8 scores, the lower the risk of dying from CVD and all-cause. Following adjustment for age, alcohol consumption, and socio-economic status, every 50-unit increase in LE8 score was associated with 17% and 14% lower risk of CVD and all-cause deaths, respectively. Men within LE8 top quartile had 60% lower risk of CVD mortality when compared with those within the bottom quartile.
Life\'s Essential 8 was strongly and inversely associated with the risk of CVD death and all-cause mortality among ageing men. Measures that promote optimal LE8 scores should be encouraged among the general population.
The association between the American Heart Association’s Life’s Essential 8 (LE8) and the risk of cardiovascular and all-cause mortality was examined using the Kuopio Ischaemic Heart Disease Risk Factor Study in Finland. The result supports continuous improvement in healthy behaviours and factors used in generating LE8 score, which may lower future risk of dying from heart disease. In this paper: • Men who had total LE8 score more than 550 had lower risk of dying from heart disease or any cause of death compared with those with LE8 score ≤ 420. • Increasing LE8 score by 50 can lower risk of dying from heart disease or any other cause.
摘要：
目的：研究生命要素8（LE8）与心血管疾病和全因死亡风险之间的关系。
方法：计算了1662名男性的LE8，年龄42至60岁，在Kuopio缺血性心脏病研究中，基线时没有预先存在的CVD病史。LE8因素包括饮食，身体活动,尼古丁暴露,睡眠,身体质量指数,血压,血糖和血脂。每个LE8因子得分在0到100分之间。所有点的总和产生总LE8得分，分为四分位数-≤420；>420至485；>485至550；和>550。多变量Cox回归模型用于估计结果的LE8评分的风险比和95%置信区间。
结果：在30年的中位随访中，402和987人死于心血管疾病和任何原因，分别。参与者的LE8总得分在185到750之间。LE8评分越高，死于心血管疾病和所有原因的风险越低。根据年龄调整后，酒精消费和社会经济地位，LE8评分每增加50个单位，CVD和全因死亡的风险降低17%和14%，分别。LE8前四分位数的男性与下四分位数的男性相比，CVD死亡率的风险降低了60％。
结论：生活要点8与老年男性心血管疾病死亡和全因死亡的风险呈强烈负相关。应鼓励在一般人群中促进最佳LE8得分的措施。
使用芬兰的Kuopio缺血性心脏病危险因素研究，研究了美国心脏协会的生命必需8（LE8）与心血管疾病和全因死亡风险之间的关联。结果支持健康行为和用于产生LE8评分的因素的持续改善，这可能会降低未来死于心脏病的风险。与LE8评分≤420的男性相比，LE8总评分超过550的男性死于心脏病或任何死亡原因的风险较低。将LE8评分提高50可以降低死于心脏病或任何其他原因的风险。
方法：计算了1662名男性的LE8，年龄42至60岁，在Kuopio缺血性心脏病研究中，基线时没有预先存在的CVD病史。LE8因素包括饮食，身体活动,尼古丁暴露,睡眠,身体质量指数,血压,血糖和血脂。每个LE8因子得分在0到100分之间。所有点的总和产生总LE8得分，分为四分位数-≤420；>420至485；>485至550；和>550。多变量Cox回归模型用于估计结果的LE8评分的风险比和95%置信区间。
结果：在30年的中位随访中，402和987人死于心血管疾病和任何原因，分别。参与者的LE8总得分在185到750之间。LE8评分越高，死于心血管疾病和所有原因的风险越低。根据年龄调整后，酒精消费和社会经济地位，LE8评分每增加50个单位，CVD和全因死亡的风险降低17%和14%，分别。LE8前四分位数的男性与下四分位数的男性相比，CVD死亡率的风险降低了60％。
结论：生活要点8与老年男性心血管疾病死亡和全因死亡的风险呈强烈负相关。应鼓励在一般人群中促进最佳LE8得分的措施。
使用芬兰的Kuopio缺血性心脏病危险因素研究，研究了美国心脏协会的生命必需8（LE8）与心血管疾病和全因死亡风险之间的关联。结果支持健康行为和用于产生LE8评分的因素的持续改善，这可能会降低未来死于心脏病的风险。与LE8评分≤420的男性相比，LE8总评分超过550的男性死于心脏病或任何死亡原因的风险较低。将LE8评分提高50可以降低死于心脏病或任何其他原因的风险。
