PDF(Pubmed)
Abstract：
UNASSIGNED: At present, many studies have confirmed that inflammation plays a central role in Parkinson\'s disease (PD). The inflammatory index is related to the prognosis of the disease, but a single inflammatory index has some limitations. The C-reactive protein-albumin ratio (CAR) is a better marker of inflammation or nutritional status than C-reactive protein (CRP) or albumin (Alb), but there is limited study on the association between CAR and the overall survival (OS) of PD.
UNASSIGNED: To study the association between CAR and OS in PD patients.
UNASSIGNED: All of these data were obtained from the Dryad Digital Repository, based on which we conducted a secondary analysis. The study was conducted by the Department of Neurology, the National Regional Center for Neurological Disorders, and the National Hospital of Utano study between March 2004 to November 2007. The final analytic sample included 235 PD patients with the outcome of survival or all-cause death from the study registration to the endpoint. In this study, univariate and multivariate COX regression analyses were used to calculate the adjusted hazard ratio (HR), with a 95% confidence interval (CI). In addition, the association between CAR and OS in PD patients was explored by Kaplan-Meier curve and subgroup analysis.
UNASSIGNED: This study included 235 PD patients with an average age of 62.25 years, including 135 females and 100 males, and 45 died during the follow-up period. CAR was associated with gender, modified Hoehn-Yahr stages (mH-Y), and Mini-Mental State Examination (MMSE) of PD patients. In the COX multivariate regression model, after adjusting the age, gender, PD duration, mH-Y, MMSE, and the non-steroidal anti-inflammatory drugs, CAR was found to be associated with the OS in PD (HR = 1.54, 95% CI = 1.01-2.34, p = 0.044). Subgroup analysis showed that the subgroup did not play an interactive role in the association between the prognosis of patients with CAR and PD (p for interaction >0.05), and the results remained stable.
UNASSIGNED: The all-cause mortality of PD patients with a high level of CAR is higher, which indicates that the poor overall survival of PD patients is associated with the increase of CAR. The CAR may be a reliable prognostic biomarker for PD patients.
UNASSIGNED: To study the association between CAR and OS in PD patients.
UNASSIGNED: All of these data were obtained from the Dryad Digital Repository, based on which we conducted a secondary analysis. The study was conducted by the Department of Neurology, the National Regional Center for Neurological Disorders, and the National Hospital of Utano study between March 2004 to November 2007. The final analytic sample included 235 PD patients with the outcome of survival or all-cause death from the study registration to the endpoint. In this study, univariate and multivariate COX regression analyses were used to calculate the adjusted hazard ratio (HR), with a 95% confidence interval (CI). In addition, the association between CAR and OS in PD patients was explored by Kaplan-Meier curve and subgroup analysis.
UNASSIGNED: This study included 235 PD patients with an average age of 62.25 years, including 135 females and 100 males, and 45 died during the follow-up period. CAR was associated with gender, modified Hoehn-Yahr stages (mH-Y), and Mini-Mental State Examination (MMSE) of PD patients. In the COX multivariate regression model, after adjusting the age, gender, PD duration, mH-Y, MMSE, and the non-steroidal anti-inflammatory drugs, CAR was found to be associated with the OS in PD (HR = 1.54, 95% CI = 1.01-2.34, p = 0.044). Subgroup analysis showed that the subgroup did not play an interactive role in the association between the prognosis of patients with CAR and PD (p for interaction >0.05), and the results remained stable.
UNASSIGNED: The all-cause mortality of PD patients with a high level of CAR is higher, which indicates that the poor overall survival of PD patients is associated with the increase of CAR. The CAR may be a reliable prognostic biomarker for PD patients.
摘要：
未经批准：目前，许多研究证实，炎症在帕金森病（PD）中起着重要作用。炎症指标与疾病的预后有关，但单一的炎症指数有一定的局限性。与C反应蛋白（CRP）或白蛋白（Alb）相比，C反应蛋白-白蛋白比（CAR）是更好的炎症或营养状况标志物。但是关于CAR与PD总生存期（OS）之间的关系的研究有限。
未经批准：研究PD患者的CAR和OS之间的关联。
UNASSIGNED：所有这些数据都是从DryadDigitalRepository获得的，在此基础上，我们进行了二次分析。这项研究是由神经内科进行的，国家区域神经疾病中心，和Utano国家医院在2004年3月至2007年11月之间的研究。最终的分析样本包括235名PD患者，从研究注册到终点的生存或全因死亡。在这项研究中,单变量和多变量COX回归分析用于计算调整后的风险比(HR)，95%置信区间(CI)。此外,本研究通过Kaplan-Meier曲线和亚组分析探讨了PD患者中CAR和OS的相关性.
UNASSIGNED：这项研究包括235名PD患者，平均年龄为62.25岁，包括135名女性和100名男性，45人在随访期间死亡。CAR与性别有关，改良的Hoehn-Yahr阶段(MH-Y)，和PD患者的简易精神状态检查(MMSE)。在COX多元回归模型中，在调整了年龄之后,性别,PD持续时间,mH-Y,MMSE,和非甾体抗炎药，发现CAR与PD中的OS相关(HR=1.54,95%CI=1.01-2.34,p=0.044)。亚组分析表明，亚组在CAR和PD患者的预后之间没有相互作用的作用（p为相互作用>0.05），结果保持稳定。
UASSIGNED：CAR水平较高的PD患者的全因死亡率较高，这表明PD患者总体生存率差与CAR的增加有关。CAR可能是PD患者的可靠预后生物标志物。
未经批准：研究PD患者的CAR和OS之间的关联。
UNASSIGNED：所有这些数据都是从DryadDigitalRepository获得的，在此基础上，我们进行了二次分析。这项研究是由神经内科进行的，国家区域神经疾病中心，和Utano国家医院在2004年3月至2007年11月之间的研究。最终的分析样本包括235名PD患者，从研究注册到终点的生存或全因死亡。在这项研究中,单变量和多变量COX回归分析用于计算调整后的风险比(HR)，95%置信区间(CI)。此外,本研究通过Kaplan-Meier曲线和亚组分析探讨了PD患者中CAR和OS的相关性.
UNASSIGNED：这项研究包括235名PD患者，平均年龄为62.25岁，包括135名女性和100名男性，45人在随访期间死亡。CAR与性别有关，改良的Hoehn-Yahr阶段(MH-Y)，和PD患者的简易精神状态检查(MMSE)。在COX多元回归模型中，在调整了年龄之后,性别,PD持续时间,mH-Y,MMSE,和非甾体抗炎药，发现CAR与PD中的OS相关(HR=1.54,95%CI=1.01-2.34,p=0.044)。亚组分析表明，亚组在CAR和PD患者的预后之间没有相互作用的作用（p为相互作用>0.05），结果保持稳定。
UASSIGNED：CAR水平较高的PD患者的全因死亡率较高，这表明PD患者总体生存率差与CAR的增加有关。CAR可能是PD患者的可靠预后生物标志物。
