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Abstract：
Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], P = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], P < 0.001) and IFIH1 rs10930046-C allele (additive model: adjusted OR = 1.26, 95% CI [1.07-1.49], P = 0.005) were associated with chronic hepatitis C (CHC). And the risk of CHC increased in people carrying more unfavorable genotypes (rs2074158-AG/GG or rs10930046-CC), with the chronic rates for genotypes number from zero to two in 60.69%, 57.33%, and 85.93%, respectively (adjusted OR = 3.64, 95% CI [2.18-6.08]; P < 0.001). Genetic polymorphism of IFIH1 and DHX58 may be related to CHC in the Chinese Han population. Furthermore, the risk of CHC increases as the number of unfavorable genotypes carried by the HCV-infected person increases. IFIH1 rs10930046, DHX58 rs2074158, age, ALT, and AST levels were all independent predictors of CHC.
摘要：
丙型肝炎仍然是世界上主要的公共卫生问题。宿主免疫系统在病毒清除中起关键作用。本研究旨在探讨中国汉族人群中维甲酸诱导基因I-like(RIG-I-like)受体基因多态性与丙型肝炎慢性化的关系。本研究对三个SNP（IFIH1rs10930046和DHX58rs2074158，rs2074160）进行了基因分型，以评估其与1,590名参与者（590例自发性HCV清除病例和1,000例持续性感染患者）中丙型肝炎病毒（HCV）感染的慢性相关性。我们的研究表明DHX58rs2074158-G等位基因(显性模型:调整OR=1.53,95%CI[1.20-1.95],P=0.001；加法模型：调整后OR=1.50，95%CI[1.27-1.78]，P<0.001）和IFIH1rs10930046-C等位基因（相加模型：调整后的OR=1.26，95％CI[1.07-1.49]，P=0.005）与慢性丙型肝炎（CHC）相关。携带更多不良基因型（rs2074158-AG/GG或rs10930046-CC）的人群中CHC的风险增加，基因型从零到二的慢性比率为60.69%，57.33%,85.93%，分别(校正后OR=3.64，95%CI[2.18-6.08]；P<0.001)。IFIH1和DHX58的遗传多态性可能与中国汉族人群的CHC有关。此外，CHC的风险随着HCV感染者携带的不良基因型数量的增加而增加.IFIH1rs10930046,DHX58rs2074158,年龄,ALT,AST水平均为CHC的独立预测因子。
