关键词: cryptorchidism hormonal therapy idiopathic hypogonadotropic hypogonadism spermatogenesis testicular descent

Mesh : Male Humans Adult Cryptorchidism / drug therapy Retrospective Studies Hypogonadism / drug therapy

来  源:   DOI:10.3389/fendo.2022.1095950   PDF(Pubmed)

Abstract:
UNASSIGNED: Hormonal therapy is a reasonable treatment for cryptorchidism caused by idiopathic hypogonadotropic hypogonadism (IHH). However, the clinical evidence on whether it is effective and safe for the treatment of cryptorchidism caused by IHH is lacking.
UNASSIGNED: To evaluate the effect of hormonal therapy in testicular descent, puberty development, and spermatogenesis in adult males with cryptorchidism caused by IHH.
UNASSIGNED: This retrospective study included 51 patients with cryptorchidism caused by IHH from the Andrology Clinic of University affiliated teaching hospital. Patients were divided into two groups: group A patients received hormonal therapy; group B patients received surgical treatment for cryptorchidism followed by hormonal therapy.
UNASSIGNED: The rate of successful testicular descent following hormonal therapy (19/32 in group A) or surgical treatment (11/19 in group B) shows no statistically significant difference. There was also no statistically significant difference in penile length, Tanner stage of pubic hair, testicular volume, and success rate of spermatogenesis between the two groups. Testicular atrophy was seen in a single patient in group B.
UNASSIGNED: Hormone therapy in adult males with cryptorchidism caused by IHH is effective and safe regarding testicular descent, puberty development, and spermatogenesis. This study provides new insight into the treatment of cryptorchidism caused by IHH and highlights that hormonal therapy could be an effective, safe, and economic treatment option for cryptorchidism in males caused by IHH.
摘要:
UNASSIGNED:激素疗法是特发性低促性腺激素性性腺功能减退症(IHH)引起的隐睾的合理治疗方法。然而,目前尚缺乏临床证据证明其治疗IHH引起的隐睾是否有效和安全。
未经评估:为了评估激素治疗对睾丸下降的影响,青春期发育,和由IHH引起的隐睾成年男性的精子发生。
UNASSIGNED:这项回顾性研究包括来自大学附属教学医院男科诊所的51例IHH引起的隐睾患者。患者分为两组:A组患者接受激素治疗;B组患者接受隐睾手术治疗,然后进行激素治疗。
UNASSIGNED:激素治疗(A组19/32)或手术治疗(B组11/19)后睾丸下降成功率无统计学差异。阴茎长度也没有统计学上的显著差异,阴毛的制革阶段,睾丸体积,两组的生精成功率。B组1例患者出现睾丸萎缩。
UNASSIGNED:在由IHH引起的隐睾成年男性中,激素治疗对于睾丸下降是有效和安全的,青春期发育,和精子发生。这项研究为IHH引起的隐睾治疗提供了新的见解,并强调激素治疗可能是一种有效的,安全,和IHH引起的男性隐睾的经济治疗选择。
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