PDF(Pubmed)
Abstract：
Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. To date, no technology has achieved long-term sustainable patient-derived organ generation. In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology.
摘要：
数百万人患有终末期难治性疾病。绝症患者的理想治疗选择是器官移植。然而,供体器官绝对短缺，可悲的是，大多数病人在等待捐献器官时死亡。迄今为止,没有一项技术实现了长期可持续的患者来源的器官生成。在这方面,通过胚泡互补（BC）产生嵌合人体器官的新兴技术前景广阔。通过BC进行人体器官的生成和移植到下一步，我们从发育生物学的角度回顾了当前新兴的器官生成技术以及人类细胞中嵌合体形成的相关效率。
