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Abstract：
Gingivobuccal and oral tongue squamous cell carcinomas are commonly considered together as a single clinical entity for staging and treatment purposes. Though there is data suggesting a significant difference between SCC of various oral cavity subsites, very few studies have compared clinicopathological characteristics between the tongue and gingivobuccal primaries. We retrospectively analysed 225 patients with biopsy-proven gingivobuccal (GB) and oral tongue (OT) SCC operated between April 1, 2018 and April 30, 2021 in All India Institute of Medical Sciences, Rishikesh, India to compare their clinicopathological characteristics. Demographic, clinical and histopathological data were collected from electronic medical records. An independent sample t-test was used to compare means and Pearson chi-square test or Fisher exact test was applied to compare the distribution of categorical variables. A relative male preponderance (12:1 vs. 5:1, p = 0.036) and increased smokeless tobacco consumption (82% Vs. 69%, p = 0.003) was seen in GB-SCC. Significantly higher proportion of patients with OT-SCC presented with early primaries (T1/T2) (54.1% vs. 24.8%, p < 0.001). Similarly, a higher proportion of GB-SCC patients presented with palpable neck nodes (cN +) (81% Vs. 67%, p = 0.02). Due to early primary tumours at presentation, stage I/II disease was also significantly higher in cases of OT-SCC (36.5% Vs.13.7%, p < 0.001). No difference was noticed in age at presentation, neck node status, and other clinicopathological parameters. GB-SCC has a higher male preponderance than OT-SCC due to relatively higher consumption of smokeless tobacco in males. Oral tongue cancers presented at an earlier stage than gingivobuccal malignancies. No difference in neck node status, however, suggests a relatively aggressive disease behaviour and early regional metastasis in tongue cancers. Follow up data regarding recurrence and survival is required to further characterise the differences between these two common OSCC subsites.
摘要：
通常将牙龈和口腔舌鳞状细胞癌一起视为用于分期和治疗目的的单一临床实体。尽管有数据表明各种口腔亚位点的SCC之间存在显着差异，很少有研究比较舌和牙龈颊初级的临床病理特征。我们回顾性分析了在2018年4月1日至2021年4月30日期间在全印度医学研究所手术的225例经活检证实的牙龈颊（GB）和口腔舌（OT）SCC患者。Rishikesh,印度比较其临床病理特征。人口统计,从电子病历中收集临床和组织病理学数据.采用独立样本t检验比较均值，采用Pearson卡方检验或Fisher精确检验比较分类变量的分布。相对男性优势（12：1vs.5：1，p=0.036）和无烟烟草消费量增加（82％Vs。69%,p=0.003）在GB-SCC中可见。早期原发性（T1/T2）的OT-SCC患者比例明显更高（54.1％vs.24.8%,p<0.001)。同样，GB-SCC患者中出现可触及颈部淋巴结(cN+)的比例较高(81%Vs.67%,p=0.02)。由于早期原发性肿瘤，在OT-SCC病例中，I/II期疾病也显着较高（36.5％Vs.13％，p<0.001)。演示时没有注意到年龄上的差异，颈部节点状态，和其他临床病理参数。GB-SCC比OT-SCC具有更高的男性优势，因为男性无烟烟草的消费量相对较高。口腔舌癌比牙龈颊恶性肿瘤更早出现。颈淋巴结状态没有差异，然而,提示舌癌中相对侵袭性的疾病行为和早期区域转移。需要关于复发和存活的后续数据来进一步表征这两个常见OSCC亚位点之间的差异。
