PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of this study was to describe the clinical presentation and outcome of patients with adult-onset recurrent respiratory papillomatosis (AoRRP) in a developing country with the challenges of poor health care access and high prevalence of HIV infection.
UNASSIGNED: This was a retrospective study of patients diagnosed with AoRRP who were managed in the Department of Otorhinolaryngology at Universitas Academic Hospital in Bloemfontein, South Africa over a 10 year period.
UNASSIGNED: There were a total of 41 patients, of which 26 (63.4%) were male. The age at diagnosis ranged between 16.4 and 67.4 years (mean 39.4 ± 14.9 years). All patients presented with a hoarse voice, with three patients also having upper airway obstruction. Eight (19.5%) patients were HIV positive. HPV typing was performed in 29 patients; 14 had HPV11 disease, 12 had HPV6 disease and in 3 patients HPV DNA was not detected. There was no significant difference in initial presentation or outcome between HIV negative and HIV positive patients, or between patients with HPV6 and HPV11 disease. Two patients had malignant transformation of the papillomas. In both these patients, HPV was not detected in the papillomas.
UNASSIGNED: HPV type and HIV infection did not appear to influence the clinical presentation and outcome in patients with AoRRP. There is a risk of malignant transformation in patients in which HPV is not detected in the papillomas.
UNASSIGNED: This was a retrospective study of patients diagnosed with AoRRP who were managed in the Department of Otorhinolaryngology at Universitas Academic Hospital in Bloemfontein, South Africa over a 10 year period.
UNASSIGNED: There were a total of 41 patients, of which 26 (63.4%) were male. The age at diagnosis ranged between 16.4 and 67.4 years (mean 39.4 ± 14.9 years). All patients presented with a hoarse voice, with three patients also having upper airway obstruction. Eight (19.5%) patients were HIV positive. HPV typing was performed in 29 patients; 14 had HPV11 disease, 12 had HPV6 disease and in 3 patients HPV DNA was not detected. There was no significant difference in initial presentation or outcome between HIV negative and HIV positive patients, or between patients with HPV6 and HPV11 disease. Two patients had malignant transformation of the papillomas. In both these patients, HPV was not detected in the papillomas.
UNASSIGNED: HPV type and HIV infection did not appear to influence the clinical presentation and outcome in patients with AoRRP. There is a risk of malignant transformation in patients in which HPV is not detected in the papillomas.
摘要：
UNASSIGNED：这项研究的目的是描述发展中国家成人复发性呼吸道乳头状瘤病（AoRRP）患者的临床表现和结果，这些患者面临着医疗保健服务不足和艾滋病毒感染率高的挑战。
UNASSIGNED：这是一项对在布隆方丹大学学术医院耳鼻咽喉科治疗的AoRRP患者的回顾性研究，南非超过10年。
未经授权：共有41名患者，其中26人(63.4%)为男性。诊断年龄在16.4至67.4岁之间（平均39.4±14.9岁）。所有的病人都有嘶哑的声音,三名患者也有上呼吸道阻塞。8名（19.5%）患者为HIV阳性。29例患者进行了HPV分型；14例有HPV11病，12例患有HPV6疾病，3例患者未检测到HPVDNA。HIV阴性和HIV阳性患者的初始表现或结果没有显着差异，或在HPV6和HPV11疾病患者之间。两名患者发生乳头状瘤的恶变。在这两个病人中，在乳头状瘤中未检测到HPV。
未经证实：HPV类型和HIV感染似乎并未影响AoRRP患者的临床表现和结果。在乳头状瘤中未检测到HPV的患者中存在恶性转化的风险。
UNASSIGNED：这是一项对在布隆方丹大学学术医院耳鼻咽喉科治疗的AoRRP患者的回顾性研究，南非超过10年。
未经授权：共有41名患者，其中26人(63.4%)为男性。诊断年龄在16.4至67.4岁之间（平均39.4±14.9岁）。所有的病人都有嘶哑的声音,三名患者也有上呼吸道阻塞。8名（19.5%）患者为HIV阳性。29例患者进行了HPV分型；14例有HPV11病，12例患有HPV6疾病，3例患者未检测到HPVDNA。HIV阴性和HIV阳性患者的初始表现或结果没有显着差异，或在HPV6和HPV11疾病患者之间。两名患者发生乳头状瘤的恶变。在这两个病人中，在乳头状瘤中未检测到HPV。
未经证实：HPV类型和HIV感染似乎并未影响AoRRP患者的临床表现和结果。在乳头状瘤中未检测到HPV的患者中存在恶性转化的风险。
