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Abstract：
The bacteriological and antimicrobial sensitivity profile of chronic otitis media (COM) varies from region to region and from time to time and may vary among different age group as well. It was against this backdrop of the changing bacteriological profile and sensitivity pattern together with the paucity of categorically separated data of pediatric and adult population, that the present study was undertaken. A total of 193 patients of clinical diagnosis of cholesteatomatous COM with ear discharge and positive culture results were included in the study. Pus sample was collected under aseptic conditions and cultured on solid media and broth. Isolates were identified via standard biochemical tests and sensitivity patterns analysed. Chi square (χ2) test was used to analyse the significance. Pseudomonas was the most common isolate in both the pediatric (37.80%) and adult (51.46%) population. Methicillin sensitive staph aureus (MSSA) was found exclusively in pediatric population (p = 0.003).Piperacillin-Tazobactam combination was the single most effective drug regimen overall. 75% of pseudomonas isolates in pediatric and 87.5% in adults were sensitive to this regimen in vitro. Amikacin was the next most effective drug with 56.69% sensitivity in pediatric and 64.08% sensitivity in adult population. The present study finds piperacillin-tazobactam as the most effective therapy and pseudomonas as the most common isolate in the study population.In order to address the varying and changing bacteriological and sensitivity profile of chronic otitis media occurring among different geographical regions and also within a region over time, the authors recommend its periodic evaluation.
摘要：
慢性中耳炎（COM）的细菌学和抗菌敏感性特征因地区和地区而异，并且在不同年龄段之间也可能有所不同。正是在这种背景下，细菌学特征和敏感性模式不断变化，以及儿童和成人人群分类分离数据的匮乏，进行了本研究。该研究共纳入193例临床诊断为胆脂瘤性COM并伴有耳部分泌物和培养结果阳性的患者。在无菌条件下收集脓液样品并在固体培养基和肉汤上培养。通过标准的生化测试和敏感性模式分析鉴定分离物。采用卡方(χ2)检验进行显著性分析。假单胞菌是儿童（37.80％）和成人（51.46％）人群中最常见的分离株。甲氧西林敏感金黄色葡萄球菌（MSSA）仅在儿科人群中发现（p=0.003）。哌拉西林-他唑巴坦组合是总体上最有效的单一药物方案。75％的儿科假单胞菌分离株和87.5％的成年人对该方案在体外敏感。阿米卡星是下一个最有效的药物，在儿科人群中的敏感性为56.69％，在成年人群中的敏感性为64.08％。本研究发现哌拉西林他唑巴坦是最有效的治疗方法，假单胞菌是研究人群中最常见的分离株。为了解决不同地理区域之间以及随着时间的推移在一个区域内发生的慢性中耳炎的细菌学和敏感性变化。作者建议对其进行定期评估。
