PDF(Pubmed)
Abstract：
We describe the first case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma. Our patient presented with progressive unsteadiness and numbness involving bilateral upper and lower limbs. He had symmetrical length-dependent lower motor neuron pattern of weakness and numbness involving both small and large fibres with prominent sensory ataxia. An extended workup for the polyneuropathy involving a serum paraneoplastic antineuronal antibody panel showed a positive reaction for anti-CV2 antibody. CT scan of the thorax, abdomen and pelvis revealed a right upper lung nodule and histopathological examination of the nodule revealed lung adenocarcinoma. He was scheduled for chemotherapy following his discharge and there was improvement of his sensorimotor polyneuropathy following his chemotherapy.
摘要：
我们描述了第一例与肺腺癌相关的抗CV2副肿瘤性多发性神经病。我们的患者表现为双侧上肢和下肢的进行性不稳定和麻木。他具有对称的长度依赖性下运动神经元无力和麻木模式，涉及小纤维和大纤维，并伴有明显的感觉共济失调。涉及血清副肿瘤抗神经元抗体组的多发性神经病的长期检查显示，抗CV2抗体呈阳性反应。胸部CT扫描,腹部和骨盆显示右上肺结节，结节的组织病理学检查显示肺腺癌。出院后，他计划接受化疗，化疗后感觉运动性多发性神经病得到改善。
