PDF(Pubmed)
Abstract：
Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they play pivotal regulatory roles in the occurrence and development of tumors, including tumor immune escape. Due to the diversity of functional domains of TRIM family proteins, they can extensively participate in multiple signaling pathways of tumor immune escape through different substrates. In current research and clinical contexts, immune escape has become an urgent problem. The extensive participation of TRIM family proteins in curing tumors or preventing postoperative recurrence and metastasis makes them promising targets.
The aim of the review is to make up for the gap in the current research on TRIM family proteins and tumor immune escape and propose future development directions according to the current progress and problems.
This up-to-date review summarizes the characteristics and biological functions of TRIM family proteins, discusses the mechanisms of TRIM family proteins involved in tumor immune escape, and highlights the specific mechanism from the level of structure-function-molecule-pathway-phenotype, including mechanisms at the level of protein domains and functions, at the level of molecules and signaling pathways, and at the level of cells and microenvironments. We also discuss the application potential of TRIM family proteins in tumor immunotherapy, such as possible treatment strategies for combination targeting TRIM family protein drugs and checkpoint inhibitors for improving cancer treatment.
The aim of the review is to make up for the gap in the current research on TRIM family proteins and tumor immune escape and propose future development directions according to the current progress and problems.
This up-to-date review summarizes the characteristics and biological functions of TRIM family proteins, discusses the mechanisms of TRIM family proteins involved in tumor immune escape, and highlights the specific mechanism from the level of structure-function-molecule-pathway-phenotype, including mechanisms at the level of protein domains and functions, at the level of molecules and signaling pathways, and at the level of cells and microenvironments. We also discuss the application potential of TRIM family proteins in tumor immunotherapy, such as possible treatment strategies for combination targeting TRIM family protein drugs and checkpoint inhibitors for improving cancer treatment.
摘要：
背景：三部分基序（TRIM）家族蛋白有80多个成员，广泛存在于各种真核细胞中。大多数TRIM家族蛋白作为E3-泛素连接酶参与泛素-蛋白酶体降解系统;它们在肿瘤的发生和发展中起着关键的调节作用，包括肿瘤免疫逃逸。由于TRIM家族蛋白的功能域的多样性,它们可以通过不同的底物广泛参与肿瘤免疫逃逸的多条信号通路。在目前的研究和临床背景下，免疫逃逸已经成为一个亟待解决的问题。TRIM家族蛋白在治疗肿瘤或预防术后复发和转移中的广泛参与使其成为有希望的靶标。
目的：综述本综述旨在弥补目前TRIM家族蛋白与肿瘤免疫逃逸研究的空白，并根据目前的进展和存在的问题提出未来的发展方向。这篇最新的综述总结了TRIM家族蛋白的特征和生物学功能，讨论了TRIM家族蛋白参与肿瘤免疫逃逸的机制，并从结构-功能-分子-途径-表型的水平突出了具体机制，包括蛋白质结构域和功能水平的机制，在分子和信号通路的水平，在细胞和微环境的水平。我们还讨论了TRIM家族蛋白在肿瘤免疫治疗中的应用潜力，例如针对TRIM家族蛋白药物和检查点抑制剂的联合治疗策略，以改善癌症治疗。
目的：综述本综述旨在弥补目前TRIM家族蛋白与肿瘤免疫逃逸研究的空白，并根据目前的进展和存在的问题提出未来的发展方向。这篇最新的综述总结了TRIM家族蛋白的特征和生物学功能，讨论了TRIM家族蛋白参与肿瘤免疫逃逸的机制，并从结构-功能-分子-途径-表型的水平突出了具体机制，包括蛋白质结构域和功能水平的机制，在分子和信号通路的水平，在细胞和微环境的水平。我们还讨论了TRIM家族蛋白在肿瘤免疫治疗中的应用潜力，例如针对TRIM家族蛋白药物和检查点抑制剂的联合治疗策略，以改善癌症治疗。
