Abstract：
OBJECTIVE: To evaluate the effect of subgingival administration of various antimicrobials and host-modulating agents in furcation defects as an adjunct to scaling and root planing (SRP) compared to SRP alone or combined with placebo.
METHODS: A systematic review was carried out using MEDLINE-PubMed, Embase, and Scopus for articles up to October 2022 in addition to hand searches. All longitudinal studies that evaluated the effect of subgingival application of antimicrobial and host-modulating agents in furcation defects as adjuncts to SRP compared to SRP alone or SRP + placebo with at least 3 months of follow-up were eligible for inclusion.
RESULTS: A total of eight studies were included. Superior clinical treatment outcomes were shown when alendronate, rosuvastatin, boric acid, simvastatin, and tetracycline (only at 3 months) were utilized in furcation defects in conjunction with SRP alone or SRP + placebo. Significant improvement was reported in radiographic bone defect depth and defect depth reduction when SRP was supplemented with alendronate, rosuvastatin, boric acid, and simvastatin.
CONCLUSIONS: Within the limitations of this review, the adjunctive subgingival administration of medications and host-modulating agents in furcation defects may confer additional clinical and radiographic benefits than non-surgical periodontal treatment alone. Future investigations are needed to confirm their long-term effectiveness.
CONCLUSIONS: Local host modulators and antimicrobials may be used supplementary to enhance the clinical and radiographic treatment outcomes of conventional periodontal therapy in furcation defects.
METHODS: A systematic review was carried out using MEDLINE-PubMed, Embase, and Scopus for articles up to October 2022 in addition to hand searches. All longitudinal studies that evaluated the effect of subgingival application of antimicrobial and host-modulating agents in furcation defects as adjuncts to SRP compared to SRP alone or SRP + placebo with at least 3 months of follow-up were eligible for inclusion.
RESULTS: A total of eight studies were included. Superior clinical treatment outcomes were shown when alendronate, rosuvastatin, boric acid, simvastatin, and tetracycline (only at 3 months) were utilized in furcation defects in conjunction with SRP alone or SRP + placebo. Significant improvement was reported in radiographic bone defect depth and defect depth reduction when SRP was supplemented with alendronate, rosuvastatin, boric acid, and simvastatin.
CONCLUSIONS: Within the limitations of this review, the adjunctive subgingival administration of medications and host-modulating agents in furcation defects may confer additional clinical and radiographic benefits than non-surgical periodontal treatment alone. Future investigations are needed to confirm their long-term effectiveness.
CONCLUSIONS: Local host modulators and antimicrobials may be used supplementary to enhance the clinical and radiographic treatment outcomes of conventional periodontal therapy in furcation defects.
摘要：
目的：与单独使用SRP或与安慰剂联合使用SRP相比，评估牙龈下施用各种抗微生物剂和宿主调节剂在分叉缺陷中作为鳞屑和根平整（SRP）的辅助作用。
方法：使用MEDLINE-PubMed进行了系统评价，Embase,和Scopus的文章，直到2022年10月，除了手工搜索。与单独的SRP或SRP安慰剂相比，在至少3个月的随访中，评估在分叉缺陷中应用抗菌剂和宿主调节剂作为SRP的辅助作用的所有纵向研究均符合纳入条件。
结果：共纳入8项研究。当阿仑膦酸盐，瑞舒伐他汀,硼酸,辛伐他汀,四环素（仅在3个月时）与单独的SRP或SRP安慰剂一起用于分叉缺陷。据报道，当SRP补充阿仑膦酸盐时，放射学骨缺损深度和缺损深度减少显著改善。瑞舒伐他汀,硼酸,还有辛伐他汀.
结论：在本综述的局限性内，与单用非手术牙周治疗相比,在分叉缺损患者中,牙龈下辅助给药药物和宿主调节剂可带来额外的临床和影像学益处.需要进一步调查以确认其长期有效性。
结论：局部宿主调节剂和抗微生物剂可作为补充使用，以增强常规牙周治疗在分叉缺损中的临床和影像学治疗结果。
方法：使用MEDLINE-PubMed进行了系统评价，Embase,和Scopus的文章，直到2022年10月，除了手工搜索。与单独的SRP或SRP安慰剂相比，在至少3个月的随访中，评估在分叉缺陷中应用抗菌剂和宿主调节剂作为SRP的辅助作用的所有纵向研究均符合纳入条件。
结果：共纳入8项研究。当阿仑膦酸盐，瑞舒伐他汀,硼酸,辛伐他汀,四环素（仅在3个月时）与单独的SRP或SRP安慰剂一起用于分叉缺陷。据报道，当SRP补充阿仑膦酸盐时，放射学骨缺损深度和缺损深度减少显著改善。瑞舒伐他汀,硼酸,还有辛伐他汀.
结论：在本综述的局限性内，与单用非手术牙周治疗相比,在分叉缺损患者中,牙龈下辅助给药药物和宿主调节剂可带来额外的临床和影像学益处.需要进一步调查以确认其长期有效性。
结论：局部宿主调节剂和抗微生物剂可作为补充使用，以增强常规牙周治疗在分叉缺损中的临床和影像学治疗结果。
